• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
(+)-Taxifolin

(+)-Taxifolin

Product ID T0394
Cas No. 480-18-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $56.40 In stock
25 mg $89.70 In stock
100 mg $280.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Taxifolin is a catechol-type flavonoid that displays cardioprotective, neuroprotective, antioxidative, and anticancer chemotherapeutic activities. In animal models of diabetic cardiomyopathy, taxifolin inhibits myocyte apoptosis (through inhibition of caspase-3 and caspase-9 activation, release of cytochrome c, and increases in JAK/STAT3 activation), attenuating structural pathology and improving diastolic function. Taxifolin displays neuroprotective properties in models of Alzheimer’s disease as it prevents aggregation of amyloid-β (Aβ) proteins by reacting with lysine residues. This compound also increases quinone reductase activity and decreases NADPH oxidase activity, activating the antioxidant response element (ARE). Additionally, taxifolin inhibits fatty acid synthesis and cell growth and induces apoptosis, inhibiting proliferation of cancer cells in vitro and in vivo.

Product Info

Cas No.

480-18-2

Purity

≥98%

Formula

C15H12O7

Formula Wt.

304.25

Chemical Name

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

IUPAC Name

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

Synonym

Dihydroquercetin

Melting Point

230-232°C

Solubility

DMSO (60 mg/mL); ethanol (60 mg/mL); water (<1 mg/mL).

Appearance

Light yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T0394 MSDS PDF

Info Sheet

T0394 Info Sheet PDF

References

Sato M, Murakami K, Uno M, et al. Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid-beta aggregation. Biosci Biotechnol Biochem. 2013;77(5):1100-1103. PMID: 23649236.

Sun X, Chen RC, Yang ZH, et al. Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol. 2013 Nov 20. [Epub ahead of print]. PMID: 24269735

Sato M, Murakami K, Uno M, et al. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem. 2013 Aug 9;288(32):23212-24. PMID: 23792961

Lee SB, Cha KH, Selenge D, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID: 17541156

Brusselmans K, Vrolix R, Verhoeven G, et al. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem. 2005 Feb 18;280(7):5636-45. PMID: 15533929.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E4668

    ELR-510444

    Microtubule polymerization inhibitor.

    ≥98%
  • G1651

    Geniposidic Acid

    Iridoid glucoside found in Eucommia, Castilleja...

    ≥98%
  • R2788

    RGW-611

    Morpholine derivative.

    ≥98%
  • C0344

    Calphostin C

    Found in Cladosporium; PKC inhibitor.

    ≥95%
  • A9817

    Azelaic Acid

    Dicarboxylic acid found in Arabidopsis; PPARγ ...

    ≥98%
  • C3214

    CID-797718

    Potential PKD binding agent.

    ≥99%
  • T1678

    D,L-Tetrahydropalmatine

    Alkaloid found in Corydalis and Stephania; D1/2...

    ≥98%
  • C1624

    Cefuroxime Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • C000171

    C-171

    STING inhibitor

    ≥98%
  • M5610

    Moclobemide

    MAO-A inhibitor.

    ≥98%
  • T2792

    TGX-221

    p110β PI3K inhibitor.  
  • F4532

    Flibanserin

    5-HT1A agonist, 5-HT2A antagonist.

    ≥97%
  • P1770

    Perillyl Alcohol

    Terpene found in various plant and fruit source...

    ≥85%
  • M1978

    S-(+)-Methoprene

    Juvenille insect growth hormone analog.

    ≥95%
  • P698574

    Prolylrapamycin

    Rapamycin analog

  • C3479

    Citrinin

    Mycotoxin produced by Penicillum, Aspergillus, ...

    ≥98%
  • O9702

    Ozagrel Hydrochloride

    TxA2 synthase inhibitor.

    ≥98%
  • I0482

    S-(+)-Ibuprofen

    Optically active isomer of ibuprofen, NSAID; CO...

    ≥98%
  • C3251

    Cinnarizine

    FIASMA, L-type Ca2+ channel blocker, D2 antagon...

    ≥98%
  • Q8133

    Quinacrine Dihydrochloride Dihydrate

    Cell membrane permeability modulator, topoisomeras...
    ≥97%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only