• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
(+)-Taxifolin

(+)-Taxifolin

Product ID T0394
Cas No. 480-18-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $56.40 In stock
25 mg $89.70 In stock
100 mg $280.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Taxifolin is a catechol-type flavonoid that displays cardioprotective, neuroprotective, antioxidative, and anticancer chemotherapeutic activities. In animal models of diabetic cardiomyopathy, taxifolin inhibits myocyte apoptosis (through inhibition of caspase-3 and caspase-9 activation, release of cytochrome c, and increases in JAK/STAT3 activation), attenuating structural pathology and improving diastolic function. Taxifolin displays neuroprotective properties in models of Alzheimer’s disease as it prevents aggregation of amyloid-β (Aβ) proteins by reacting with lysine residues. This compound also increases quinone reductase activity and decreases NADPH oxidase activity, activating the antioxidant response element (ARE). Additionally, taxifolin inhibits fatty acid synthesis and cell growth and induces apoptosis, inhibiting proliferation of cancer cells in vitro and in vivo.

Product Info

Cas No.

480-18-2

Purity

≥98%

Formula

C15H12O7

Formula Wt.

304.25

Chemical Name

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

IUPAC Name

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

Synonym

Dihydroquercetin

Melting Point

230-232°C

Solubility

DMSO (60 mg/mL); ethanol (60 mg/mL); water (<1 mg/mL).

Appearance

Light yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T0394 MSDS PDF

Info Sheet

T0394 Info Sheet PDF

References

Sato M, Murakami K, Uno M, et al. Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid-beta aggregation. Biosci Biotechnol Biochem. 2013;77(5):1100-1103. PMID: 23649236.

Sun X, Chen RC, Yang ZH, et al. Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol. 2013 Nov 20. [Epub ahead of print]. PMID: 24269735

Sato M, Murakami K, Uno M, et al. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem. 2013 Aug 9;288(32):23212-24. PMID: 23792961

Lee SB, Cha KH, Selenge D, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID: 17541156

Brusselmans K, Vrolix R, Verhoeven G, et al. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem. 2005 Feb 18;280(7):5636-45. PMID: 15533929.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • C5970

    Corydaline

    Alkaloid compound found in Corydalis.

    ≥94%
  • T8000

    Tubacin

    HDAC6 inhibitor.

    ≥96%
  • T6934

    Trimebutine Maleate

    L-type Ca2+ channel blocker, BK K+ channel modu...

    ≥96%
  • A7461

    Asperosaponin VI

    Triterpene saponin found in Dipsacus asper.

    ≥98%
  • N800000

    NU-2058

    CDK1/2 inhibitor.

    ≥98%
  • R2511

    RGDC

    Peptide, used to study cell-surface binding; po...

    ≥95%
  • M9634

    Myriocin

    Atypical amino acid found in Isaria sinclairi, ...

    ≥99%, TLC
  • T0077

    Transactivator of Transcription Peptide (2-4)

    Peptide, contains two cell-penetrating sequence...

    ≥95%
  • A5031

    4-Aminophenylphosphate Disodium

    Alkaline phosphatase substrate used to quantify...

    ≥98%
  • M1687

    Mevinolin

    Statin, naturally produced by mushrooms; HMG-Co...

    ≥97%
  • C7692

    CTX IV (6-12)

    Snake venom cardiotoxin found in Naja naja atra...

    ≥98%
  • P2515

    3-Phenylpropyl Isothiocyanate

    Synthetic ITC.

    ≥98%
  • A5373

    Anisomycin

    Peptidyl transferase inhibitor, protein transla...

    ≥98%
  • C9662

    Cyproterone Acetate

    Steroid; AR antagonist.

    ≥98%
  • L9602

    LY-2874455

    FGFR inhibitor.

    ≥98%
  • V2792

    VGX-1027

    TLR4 inhibitor.

    ≥98%
  • I5215

    Indolicidin

    Antimicrobial peptide.

    ≥95%
  • O4417

    Oleanolic Acid

    Triterpenoid found in Vigna angularis and Trigo...

    ≥98%
  • L0248

    Laminin Peptide YIGSR

    Laminin-derived peptapeptide.

    ≥98%
  • A7208

    Ascomycin

    FK506 analog; calcineurin inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only