• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
(+)-Taxifolin

(+)-Taxifolin

Product ID T0394
Cas No. 480-18-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $56.40 In stock
25 mg $89.70 In stock
100 mg $280.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Taxifolin is a catechol-type flavonoid that displays cardioprotective, neuroprotective, antioxidative, and anticancer chemotherapeutic activities. In animal models of diabetic cardiomyopathy, taxifolin inhibits myocyte apoptosis (through inhibition of caspase-3 and caspase-9 activation, release of cytochrome c, and increases in JAK/STAT3 activation), attenuating structural pathology and improving diastolic function. Taxifolin displays neuroprotective properties in models of Alzheimer’s disease as it prevents aggregation of amyloid-β (Aβ) proteins by reacting with lysine residues. This compound also increases quinone reductase activity and decreases NADPH oxidase activity, activating the antioxidant response element (ARE). Additionally, taxifolin inhibits fatty acid synthesis and cell growth and induces apoptosis, inhibiting proliferation of cancer cells in vitro and in vivo.

Product Info

Cas No.

480-18-2

Purity

≥98%

Formula

C15H12O7

Formula Wt.

304.25

Chemical Name

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

IUPAC Name

(2S,3S)-2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4H-chromen-4-one

Synonym

Dihydroquercetin

Melting Point

230-232°C

Solubility

DMSO (60 mg/mL); ethanol (60 mg/mL); water (<1 mg/mL).

Appearance

Light yellow powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T0394 MSDS PDF

Info Sheet

T0394 Info Sheet PDF

References

Sato M, Murakami K, Uno M, et al. Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid-beta aggregation. Biosci Biotechnol Biochem. 2013;77(5):1100-1103. PMID: 23649236.

Sun X, Chen RC, Yang ZH, et al. Taxifolin prevents diabetic cardiomyopathy in vivo and in vitro by inhibition of oxidative stress and cell apoptosis. Food Chem Toxicol. 2013 Nov 20. [Epub ahead of print]. PMID: 24269735

Sato M, Murakami K, Uno M, et al. Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues. J Biol Chem. 2013 Aug 9;288(32):23212-24. PMID: 23792961

Lee SB, Cha KH, Selenge D, et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biol Pharm Bull. 2007 Jun;30(6):1074-9. PMID: 17541156

Brusselmans K, Vrolix R, Verhoeven G, et al. Induction of cancer cell apoptosis by flavonoids is associated with their ability to inhibit fatty acid synthase activity. J Biol Chem. 2005 Feb 18;280(7):5636-45. PMID: 15533929.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M704789

    MRTX1133

    KRAS inhibitor

    ≥98%
  • R0250

    Ranatensin

    Peptide found in amphibians.

    ≥98%
  • T2833

    1-Thio-β-D-glucose Tetraacetate

    Imaging agent; Maillard reaction inhibitor.

    ≥98%
  • A0962

    Adrenocorticotropic Hormone (1-4)

    Endogenous peptide hormone fragment, involved i...

    ≥95%
  • H3272

    His Tag

    Six-histidine peptide used for affinity column ...

    ≥98%
  • A4497

    Alyssin Sulfone

    Naturally sourced ITC, sulfonyl analog of sulfo...

    ≥97%
  • S6131

    N,N-Dimethyl-Sphingosine

    PP2A activator, Sphk1 and PKC inhibitor.

    ≥98%
  • T8153

    Tunicamycin

    Nucleoside antibiotic mixture; GlcNAc phosphotr...

    ≥98%
  • G4798

    Glycitein

    Aglycone isoflavone found in soy and red clover...

    ≥98%
  • M1649

    Melanoma-associated Antigen Peptide 1 (27-35), human

    Melanoma-associated antigen.

    ≥95%
  • K0652

    Kb NB 142-70

    PKD inhibitor.

    ≥98%
  • R0348

    Ramelteon

    Melatonin analog; MT1/2 agonist.

    ≥99%
  • U6856

    Urocortin II, human

    Endogenous peptide, involved in stress signaling; ...
    ≥95%
  • A488246

    AMG-232

    MDM2-p53 inhibitor

    ≥99%
  • C1718

    Cepharanthine, 95%

    Alkaloid found in Stephania.

    ≥95%
  • S0269

    SAR245409

    Pyridopyrimidinone; PI3K and mTOR inhibitor.

    ≥96%
  • G4598

    Glycyrrhizic Acid Ammonium Hydrate

    Triterpene glycoside found in Glycyrrhiza; 11β...

    ≥93%
  • K7600

    KT5720

    PKA and PDK1 inhibitor, HCN channel blocker, po...

    ≥98%
  • M9645

    Myelin Oligodendrocyte Glycoprotein (35-55), rat

    Oligodendrocyte antigen used to induce EAE.

    ≥95%
  • A9801

    Azaperone

    Butyrophenone; α-adrenergic, D2, histamine ant...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only