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Tebipenem

Tebipenem

Product ID T162051
Cas No. 161715-21-5
Purity ≥99%
Product Unit SizeCostQuantityStock
5 mg $57.60 In stock
25 mg $177.90 In stock
100 mg $474.70 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tebipenem is a broad-spectrum carbapenem antibiotic. It is a potent inhibitor of multiple penicillin-binding proteins (PBPs) but primarily a Gram-negative PBP 2 inhibitor. It react with the highly active beta-lactamase to form enzyme-drug covalent complex that is hydrolyzed extremely slowly.

Product Info

Cas No.

161715-21-5

Purity

≥99%

Formula

C16H21N3O4S2

Formula Wt.

383.5

Chemical Name

Tebipenem

IUPAC Name

(4R,5S,6S)-3-[1-(4,5-dihydro-1,3-thiazol-2-yl)azetidin-3-yl]sulfanyl-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Synonym

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,3-[[1-(4,5-dihydro-2-thiazolyl)-3-azetidinyl]thio]-6-(1-hydroxyethyl)-4-methyl-7-oxo-, [4R-[4a,5b,6b(R*)]]-; LJC-11036; SPR994

Solubility

DMSO (45 mg/mL)

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T162051 MSDS PDF

Info Sheet

T162051 Info Sheet PDF

References

E. Lacasse, E. Brouillette, A. Larose, e tal. In Vitro Activity of Tebipenem (SPR859) against Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria. Antimicrob Agents Chemother. 63(4):e02181-18 2019.

S. Hazra, H. Xu, and J. S. Blanchard, Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry.2014; 53(22):3671-8.

Custom Order

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