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Temocapril Hydrochloride

Temocapril Hydrochloride

Product ID T1750
Cas No. 110221-44-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $142.90 In stock
25 mg $224.60 In stock
100 mg $653.30 In stock
Bulk Quote

Quicklinks

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  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
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  • Custom Order

Description

Temocapril is a thiazepine prodrug that inhibits angiotensin-converting enzyme (ACE). Temocapril exhibits antihypertensive, anti-diabetic, anti-hyperglycemic, and anti-atherosclerotic activities. Temocapril decreases blood pressure without affecting heart rate or cardiac output and improves endothelial dysfunction, vascular remodeling, insulin resistance, and renal function. In animal models, temocapril inhibits elevations in the fasting plasma glucose level and loss of pancreatic β-cells, preventing the development of hyperglycemia. In stroke-prone hypertensive rats, temocapril prolongs survival rates. In other animal models, this compound inhibits oxidative stress and atherosclerotic remodeling. Temocapril also inhibits matrix metalloproteinase 2 (MMP2), decreasing peritoneal solute transport in animal models during peritoneal dialysis, indicating potential benefit in prevention of peritoneal injury.

Product Info

Cas No.

110221-44-8

Purity

≥98%

Formula

C23H28N2O5S2 • HCl

Formula Wt.

513.07

IUPAC Name

2-[6-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-5-oxo-2-thiophen-2-yl-1, 4-thiazepan-4-yl]acetic acid;hydrochloride

Synonym

CS-622

Melting Point

196-200C (dec)

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T1750 MSDS PDF

Info Sheet

T1750 Info Sheet PDF

References

Yamamoto D, Takai S, Akimoto T, et al. Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport. Clin Exp Pharmacol Physiol. 2012 Oct;39(10):864-8. PMID: 23013132.

Kaihara M, Nakamura Y, Sugimoto T, et al. Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima Fatty rats. Acta Med Okayama. 2009 Feb;63(1):35-42. PMID: 19247421.

Nozawa M, Sugimoto K, Ohmori M, et al. Dosing time-dependent effect of temocapril on the mortality of stroke-prone spontaneously hypertensive rats. J Pharmacol Exp Ther. 2006 Jan;316(1):176-81. PMID: 16174798.

Tsuda M, Iwai M, Li JM, et al. Inhibitory effects of AT1 receptor blocker, olmesartan, and estrogen on atherosclerosis via anti-oxidative stress. Hypertension. 2005 Apr;45(4):545-51. PMID: 15723967.

Yasunari K, Maeda K, Nakamura M, et al. Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovasc Drug Rev. 2004 Fall;22(3):189-98. PMID: 15492767.

Oizumi K, Koike H, Sada T, et al. Pharmacological profiles of CS-622, a novel angiotensin converting enzyme inhibitor. Jpn J Pharmacol. 1988 Nov;48(3):349-56. PMID: 2851680.

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