• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Temocapril Hydrochloride

Temocapril Hydrochloride

Product ID T1750
Cas No. 110221-44-8
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $142.90 In stock
25 mg $224.60 In stock
100 mg $653.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Temocapril is a thiazepine prodrug that inhibits angiotensin-converting enzyme (ACE). Temocapril exhibits antihypertensive, anti-diabetic, anti-hyperglycemic, and anti-atherosclerotic activities. Temocapril decreases blood pressure without affecting heart rate or cardiac output and improves endothelial dysfunction, vascular remodeling, insulin resistance, and renal function. In animal models, temocapril inhibits elevations in the fasting plasma glucose level and loss of pancreatic β-cells, preventing the development of hyperglycemia. In stroke-prone hypertensive rats, temocapril prolongs survival rates. In other animal models, this compound inhibits oxidative stress and atherosclerotic remodeling. Temocapril also inhibits matrix metalloproteinase 2 (MMP2), decreasing peritoneal solute transport in animal models during peritoneal dialysis, indicating potential benefit in prevention of peritoneal injury.

Product Info

Cas No.

110221-44-8

Purity

≥98%

Formula

C23H28N2O5S2 • HCl

Formula Wt.

513.07

IUPAC Name

2-[6-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-5-oxo-2-thiophen-2-yl-1, 4-thiazepan-4-yl]acetic acid;hydrochloride

Synonym

CS-622

Melting Point

196-200C (dec)

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T1750 MSDS PDF

Info Sheet

T1750 Info Sheet PDF

References

Yamamoto D, Takai S, Akimoto T, et al. Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport. Clin Exp Pharmacol Physiol. 2012 Oct;39(10):864-8. PMID: 23013132.

Kaihara M, Nakamura Y, Sugimoto T, et al. Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima Fatty rats. Acta Med Okayama. 2009 Feb;63(1):35-42. PMID: 19247421.

Nozawa M, Sugimoto K, Ohmori M, et al. Dosing time-dependent effect of temocapril on the mortality of stroke-prone spontaneously hypertensive rats. J Pharmacol Exp Ther. 2006 Jan;316(1):176-81. PMID: 16174798.

Tsuda M, Iwai M, Li JM, et al. Inhibitory effects of AT1 receptor blocker, olmesartan, and estrogen on atherosclerosis via anti-oxidative stress. Hypertension. 2005 Apr;45(4):545-51. PMID: 15723967.

Yasunari K, Maeda K, Nakamura M, et al. Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovasc Drug Rev. 2004 Fall;22(3):189-98. PMID: 15492767.

Oizumi K, Koike H, Sada T, et al. Pharmacological profiles of CS-622, a novel angiotensin converting enzyme inhibitor. Jpn J Pharmacol. 1988 Nov;48(3):349-56. PMID: 2851680.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A5280

    Angiotensin II (3-8), human

    Endogenous peptide fragment, involved in vasoco...

    ≥95%
  • E7357

    Esomeprazole Potassium

    (S) isomer of omeprazole; H+/K+ ATPase and MAO-...

    ≥98%
  • I7356

    Isopropyl Thiogalactoside

    Galactose analog, allolactose mimic, induces ac...

    ≥98%
  • A5225

    α-ANP (1-28), human

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • M1744

    Melittin

    Antimicrobial peptide found in Apis mellifera.<...

    ≥95%
  • R1217

    RDEA119

    MEK1/2 inhibitor.

    ≥98%
  • C2997

    Chymostatin

    Protease inhibitor.

    ≥95% (mixture of A, B, C)
  • C5864

    Coptisine Chloride, synthetic

    Isoquinoline alkaloid found in a variety of pla...

    ≥98%
  • P577520

    Ponatinib

    pan-Bcr-Abl tyrosine kinase inhibitor.

    ≥99%
  • D0260

    DAPT

    γ-Secretase inhibitor.

    ≥98%
  • U6857

    Urodilatin CCC

    ANP fragment, natriuretic peptide; Na+/K+ ATPas...

    ≥98%
  • S6247

    Splitomicin

    SIRT1/2 inhibitor.

    ≥98%
  • S584778

    Sotorasib

    KRAS inhibitor

    ≥99%
  • D0353

    Danofloxacin Mesylate

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • S7870

    Streptozocin

    Nitrosourea-amino sugar conjugate, DNA cross-li...

    ≥98%
  • C600000

    CP 55940

    Non-selective CB receptor agonist.

    ≥97%
  • O9334

    Oxibendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • C5662

    Copper Bis-3,5-diisopropylsalicylate

    Antioxidant.

    ≥97%
  • Y4800

    YM-155

    Survivin inhibitor.

    ≥99%
  • T5871

    Torin 2

    Tricyclic benzonaphthyridinone; mTORC1/2 inhibi...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only