Tenovin-6

Name: Tenovin-6
SKU: T1853
Availability: InStock

Product ID T1853

Cas No. 1011557-82-6

Purity ≥98%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Tenovin-6 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-6 exhibits anticancer chemotherapeutic activity in several models. In chronic lymphocytic leukemia (CLL) cells, tenovin-6 increases levels of LC3-II and p62, dysregulating autophagy. In colon cancer cells, this compound increases levels of death receptor 5 (DR5), inducing apoptosis. Tenovin-6 also decreases tumor growth in animal models.

Product Info

Cas No.	1011557-82-6
Purity	≥98%
Formula	C₂₅H₃₄N₄O₂S
Formula Wt.	454.63
IUPAC Name	4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
Solubility	DMSO 98 mg/mL (215.55 mM) Water 98 mg/mL warmed (215.55 mM) Ethanol Insoluble
Appearance	Yellow solid

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	T1853 MSDS PDF
Info Sheet	T1853 Info Sheet PDF

References

Ueno T, Endo S, Saito R, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-Fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2014;21(3):155-64. PMID: 24512730.

MacCallum SF, Groves MJ, James J, et al. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 2013;3:1275. PMID: 23429453.

Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.

Brooks CL, Gu W. p53 Activation: a case against Sir. Cancer Cell. 2008 May;13(5):377-8. PMID: 18455119.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Phone
This field is for validation purposes and should be left unchanged.

Tenovin-6

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Bafilomycin A1

AWD 131-138

Cheirolin

γ-Tocotrienol

Brevetoxin 3 42-carboxylic Acid

MDL 29951

Neosolaniol

Azelastine Hydrochloride

Ergosterol

Indapamide

Taurine

Fibrinolysis Inhibiting Factor

18β-Glycyrrhetinic Acid

Cuelure

α-Melanocyte Stimulating Hormone

4-α-Phorbol-12-myristate-13-acetate

Fotemustine

Cytochalasin A

JAK2 Inhibitor V

Substance P (7-11)

Footer