LKT Labs

Biochemicals for Life Science Research

Tenovin-6

Tenovin-6

Product ID T1853
Cas No. 1011557-82-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $141.80 In stock
5 mg $498.80 In stock
25 mg $1,522.50 In stock
Bulk Quote

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Description

Tenovin-6 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-6 exhibits anticancer chemotherapeutic activity in several models. In chronic lymphocytic leukemia (CLL) cells, tenovin-6 increases levels of LC3-II and p62, dysregulating autophagy. In colon cancer cells, this compound increases levels of death receptor 5 (DR5), inducing apoptosis. Tenovin-6 also decreases tumor growth in animal models.

Product Info

Cas No.

1011557-82-6
Purity

≥98%
Formula

C25H34N4O2S
Formula Wt.

454.63
IUPAC Name

4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
Solubility

DMSO 98 mg/mL (215.55 mM) Water 98 mg/mL warmed (215.55 mM) Ethanol Insoluble
Appearance

Yellow solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T1853 MSDS PDF
Info Sheet

T1853 Info Sheet PDF

References

Ueno T, Endo S, Saito R, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-Fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2014;21(3):155-64. PMID: 24512730.

MacCallum SF, Groves MJ, James J, et al. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 2013;3:1275. PMID: 23429453.

Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.

Brooks CL, Gu W. p53 Activation: a case against Sir. Cancer Cell. 2008 May;13(5):377-8. PMID: 18455119.

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