LKT Labs

Biochemicals for Life Science Research

Tenovin-6

Tenovin-6

Product ID T1853
Cas No. 1011557-82-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $141.80 In stock
5 mg $498.80 In stock
25 mg $1,522.50 In stock
Bulk Quote

Quicklinks

Description

Tenovin-6 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-6 exhibits anticancer chemotherapeutic activity in several models. In chronic lymphocytic leukemia (CLL) cells, tenovin-6 increases levels of LC3-II and p62, dysregulating autophagy. In colon cancer cells, this compound increases levels of death receptor 5 (DR5), inducing apoptosis. Tenovin-6 also decreases tumor growth in animal models.

Product Info

Cas No.

1011557-82-6
Purity

≥98%
Formula

C25H34N4O2S
Formula Wt.

454.63
IUPAC Name

4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
Solubility

DMSO 98 mg/mL (215.55 mM) Water 98 mg/mL warmed (215.55 mM) Ethanol Insoluble
Appearance

Yellow solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T1853 MSDS PDF
Info Sheet

T1853 Info Sheet PDF

References

Ueno T, Endo S, Saito R, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-Fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2014;21(3):155-64. PMID: 24512730.

MacCallum SF, Groves MJ, James J, et al. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 2013;3:1275. PMID: 23429453.

Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.

Brooks CL, Gu W. p53 Activation: a case against Sir. Cancer Cell. 2008 May;13(5):377-8. PMID: 18455119.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S4244

    SKLB 610

    VEGFR2, PDGFR, FGFR2 inhibitor.

    ≥98%
  • Q8135

    Quinestrol

    Synthetic steroid hormone, estrogen analog, use...

    ≥98%
  • A9817

    Azelaic Acid

    Dicarboxylic acid found in Arabidopsis; PPARγ ...

    ≥98%
  • G0106

    Gabapentin

    GABA analog; GABA potentiator, adenosine A1 ago...

    ≥98%
  • S7970

    Strontium Ranelate

    Bone deterioration inhibitor, potential CaR ago...

    ≥98%
  • O783720

    OTS-964

    Inhibitor of T-lymphokine-activated killer cell...

    ≥98%
  • M1845

    Melitracen Hydrochloride

    Tricyclic antidepressant; potential D1/2 antago...

    ≥99%
  • B030964

    BAY-1816032

    BUB1 inhibitor.

    ≥99%
  • A4805

    Amastatin Hydrochloride Hydrate

    Aminopeptidase inhibitor.

    ≥98%
  • C9882

    Cytochalasin E

    Mycotoxin produced by Aspergillus; actin polyme...

    ≥98%
  • S1970

    Serum Thymic Factor

    Synthetic peptide hormone.

    ≥95%
  • M1708

    Mecamylamine Hydrochloride

    Monoterpene; nAChR antagonist.

    ≥98%
  • M578522

    Monascin

    Fungal pigment found in red yeast rice

    ≥98%
  • S0269

    SAR245409

    Pyridopyrimidinone; PI3K and mTOR inhibitor.

    ≥96%
  • C1624

    Cefuroxime Sodium

    β-lactam; penicillin binding protein inhibitor...

    ≥98%
  • T0140

    TAK-632

    RAF inhibitor.

    ≥99%
  • X4424

    XL-765

    PI3K and mTOR inhibitor.

    ≥98%
  • G1308

    GDC-0032

    PI3K inhibitor.

    ≥98%
  • K1655

    Kenpaullone

    GSK-3β, HGK, and CDK inhibitor.

    ≥95%
  • K040007

    KB-0742

    CDK9 inhibitor.

    ≥98%