LKT Labs

Biochemicals for Life Science Research

Tenovin-6

Tenovin-6

Product ID T1853
Cas No. 1011557-82-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $141.80 In stock
5 mg $498.80 In stock
25 mg $1,522.50 In stock
Bulk Quote

Quicklinks

Description

Tenovin-6 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-6 exhibits anticancer chemotherapeutic activity in several models. In chronic lymphocytic leukemia (CLL) cells, tenovin-6 increases levels of LC3-II and p62, dysregulating autophagy. In colon cancer cells, this compound increases levels of death receptor 5 (DR5), inducing apoptosis. Tenovin-6 also decreases tumor growth in animal models.

Product Info

Cas No.

1011557-82-6
Purity

≥98%
Formula

C25H34N4O2S
Formula Wt.

454.63
IUPAC Name

4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
Solubility

DMSO 98 mg/mL (215.55 mM) Water 98 mg/mL warmed (215.55 mM) Ethanol Insoluble
Appearance

Yellow solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T1853 MSDS PDF
Info Sheet

T1853 Info Sheet PDF

References

Ueno T, Endo S, Saito R, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-Fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2014;21(3):155-64. PMID: 24512730.

MacCallum SF, Groves MJ, James J, et al. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 2013;3:1275. PMID: 23429453.

Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.

Brooks CL, Gu W. p53 Activation: a case against Sir. Cancer Cell. 2008 May;13(5):377-8. PMID: 18455119.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A4678

    Alternariol-9-methyl Ether

    Mycotoxin produced by Alternaria; oxidative pho...

    ≥98%
  • B1654

    Benzyl Selenocyanate

    Organoselenium compound found in selenium-enric...

    ≥98%
  • I088240

    (S,S)-ICG-001

    Wnt/β-catenin inhibitor

    ≥98%
  • B6801

    Brassinin

    Phytoalexin, indole found in cruciferous vegeta...

    ≥98%
  • B5560

    B-type Natriuretic Peptide (1-32), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • A5056

    Amorolfine Hydrochloride

    14α-demethylase inhibitor.

    ≥98.5%
  • D3302

    Diaveridine Hydrochloride

    Coccidiostat; dihydrofolate reductase inhibitor...

    ≥98%
  • P1765

    Peptide Standard 1

    For use in amino acid analysis.

    ≥95%
  • A6132

    Apicidin

    Cyclic tetrapeptide; HDAC inhibitor.

    ≥98%
  • I0901

    Icariin

    Flavonol glycoside originally found in Epimediu...

    ≥97%
  • D3215

    Didymin

    Flavonoid glycoside found in citrus fruit.

    ≥98%
  • E7657

    Etoposide

    Podophyllotoxin derivative; topoisomerase II in...

    ≥98%
  • A0958

    Aconitine

    Toxin found in Aconitum; voltage-gated Na+ chan...

    ≥95%
  • C0265

    Carnosic Acid

    Diterpene found in Rosmarinus.

    ≥98%
  • S9753

    Synephrine

    Endogenous alkaloid also found in citrus fruits...

    ≥98%
  • O7992

    OTX-015

    BRD2/3/4 inhibitor.

    ≥98%
  • E6396

    EPZ005687

    EZH2 HMT inhibitor.

    ≥99%
  • Z4900

    ZM-447439 Trihydrate

    AurKA/B inhibitor.

    ≥99%
  • E7857

    Etofenamate

    NSAID; COX-1/2 and lipoxygenase inhibitor.

    ≥98%
  • O2144

    Ofloxacin

    Fluoroquinolone; topoisomerase IV and bacterial...

    ≥98%