LKT Labs

Biochemicals for Life Science Research

Tenovin-6

Tenovin-6

Product ID T1853
Cas No. 1011557-82-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $142.00 In stock
5 mg $499.00 In stock
25 mg $1,523.00 In stock
Bulk Quote

Quicklinks

Description

Tenovin-6 is an inhibitor of sirtuins 1 and 2 (SIRT1/2) that also indirectly activates p53; sirtuins are considered class III histone deacetylases (HDACs). Tenovin-6 exhibits anticancer chemotherapeutic activity in several models. In chronic lymphocytic leukemia (CLL) cells, tenovin-6 increases levels of LC3-II and p62, dysregulating autophagy. In colon cancer cells, this compound increases levels of death receptor 5 (DR5), inducing apoptosis. Tenovin-6 also decreases tumor growth in animal models.

Product Info

Cas No.

1011557-82-6
Purity

≥98%
Formula

C25H34N4O2S
Formula Wt.

454.63
IUPAC Name

4-tert-butyl-N-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide
Solubility

DMSO 98 mg/mL (215.55 mM) Water 98 mg/mL warmed (215.55 mM) Ethanol Insoluble
Appearance

Yellow solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T1853 MSDS PDF
Info Sheet

T1853 Info Sheet PDF

References

Ueno T, Endo S, Saito R, et al. The sirtuin inhibitor tenovin-6 upregulates death receptor 5 and enhances cytotoxic effects of 5-Fluorouracil and oxaliplatin in colon cancer cells. Oncol Res. 2014;21(3):155-64. PMID: 24512730.

MacCallum SF, Groves MJ, James J, et al. Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6. Sci Rep. 2013;3:1275. PMID: 23429453.

Lain S, Hollick JJ, Campbell J, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. PMID: 18455128.

Brooks CL, Gu W. p53 Activation: a case against Sir. Cancer Cell. 2008 May;13(5):377-8. PMID: 18455119.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B3211

    (+)-Bicuculline

    NMDA potentiator, GABA-A antagonist.

    ≥98%
  • C2960

    Chondroitin Sulfate, cow

    Polyanionic sulfated glycosaminoglycan, encogen...

    ≥90%
  • Q8016

    Quercetin Dihydrate

    Flavonoid found in fruits, vegetables, and grai...

    ≥95%
  • P7058

    Protocatechuic Aldehyde

    Polyphenol found in various plants and foods.

    ≥98%
  • E8401

    Evacetrapib

    Cholesterol ester transfer protein inhibitor.

    ≥98%
  • E499601

    Empagliflozin

    SGLT2 inhibitor

    ≥98%
  • T0251

    Tamsulosin Hydrochloride

    α1-adrenergic antagonist.

    ≥98%
  • I7559

    Isoliquiritigenin, natural

    Chalcone; SIRT activator, GABA-A positive modul...

    ≥99%
  • N8460

    NVP-BHG712

    EphB4 inhibitor.

    ≥98%
  • P0256

    Pantoprazole Sodium Sesquihydrate

    H+/K+ ATPase and ROCK-2 inhibitor.

    ≥98%
  • M1778

    S-(+)-α−Methylbenzyl Isothiocyanate

    ITC, used as chiral agent.

    ≥98%
  • L8008

    D-Luciferin, firefly, Free Acid

    Heterocyclic light-emitting compound, natural l...

    ≥98%
  • M4454

    MLN-4924

    Nedd8-activating enzyme inhibitor.

    ≥99%
  • A4443

    L-(+)-Alliin

    Optically active cysteine derivative found in A...

    ≥98%
  • S760004

    Stachybotrylactam

    Spirodihydrobenzofuranlactam

    ≥98%
  • D0363

    Daptomycin

    Anionic lipopeptide, alters cell membrane organ...

    ≥97%
  • A6269

    Apremilast

    PDE4 inhibitor.

    ≥98%
  • D0006

    Dacomitinib Monohydrate

    EGFR inhibitor.

    ≥99%
  • A4498

    Alytesin

    Antimicrobial peptide found in amphibians.

    ≥95%
  • C5968

    Cordycepin

    Nucleoside (deoxyadenosine) analog found in Co...

    ≥99%