Description
TGR5 Receptor agonist activates TGR5, a G-protein coupled receptor that increases secretion of GLP-1 from intestinal cells. This compound may amplify nutrient sensing signals and bicarbonate secretion and decrease glucose levels.
TGR5 Receptor Agonist
Product ID T2668
Cas No. 1197300-24-5
Purity ≥99%
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Product Info
| Cas No. | 1197300-24-5 |
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| Purity | ≥99% |
| Formula | C18H14Cl2N2O2 |
| Formula Wt. | 361.22 |
| IUPAC Name | 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide |
| Synonym | TGR5 |
| Solubility | Soluble in ethanol to 100 mM and in DMSO to 100 mM |
| Appearance | White to off white powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Duan H, Ning M, Chen X, et al. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J Med Chem. 2012 Dec 13;55(23):10475-89. PMID: 23148522.
Inoue T, Wang JH, Higashiyama M, et al. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G810-6. PMID: 22821947.
Evans KA, Budzik BW, Ross SA, et al. Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. J Med Chem. 2009 Dec 24;52(24):7962-5. PMID: 19902954.