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TGR5 Receptor Agonist

TGR5 Receptor Agonist

Product ID T2668
Cas No. 1197300-24-5
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $113.00 In stock
5 mg $211.00 In stock
25 mg $675.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
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Description

TGR5 Receptor agonist activates TGR5, a G-protein coupled receptor that increases secretion of GLP-1 from intestinal cells. This compound may amplify nutrient sensing signals and bicarbonate secretion and decrease glucose levels.

Product Info

Cas No.

1197300-24-5

Purity

≥99%

Formula

C18H14Cl2N2O2

Formula Wt.

361.22

IUPAC Name

3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-1,2-oxazole-4-carboxamide

Synonym

TGR5

Solubility

Soluble in ethanol to 100 mM and in DMSO to 100 mM

Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T2668 MSDS PDF

Info Sheet

T2668 Info Sheet PDF

References

Duan H, Ning M, Chen X, et al. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists. J Med Chem. 2012 Dec 13;55(23):10475-89. PMID: 23148522.

Inoue T, Wang JH, Higashiyama M, et al. Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G810-6. PMID: 22821947.

Evans KA, Budzik BW, Ross SA, et al. Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists. J Med Chem. 2009 Dec 24;52(24):7962-5. PMID: 19902954.

Custom Order

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