Description
TGX-221 is an inhibitor of PI3Kβ. It exhibits high selectivity to clear cell renal cell carcinoma with VHL and SETD2 mutations. It also inhibits cell migration and invasion, and induces apoptosis in human glioblastoma cells.
TGX-221
Product ID T2792
Cas No. 663619-89-4
Purity
| Product Unit Size | Cost | Quantity | Stock |
|---|
Product Info
| Cas No. | 663619-89-4 |
|---|---|
| Formula | C21H24N4O2 |
| Formula Wt. | 364.44 |
| IUPAC Name | 9-(1-anilinoethyl)-7-methyl-2-morpholin-4-ylpyrido[1,2-a]pyrimidin-4-one |
| Solubility | DMSO 12 mg/mL (32.92 mM) Water Insoluble Ethanol Insoluble |
| Appearance | Light Yellow Powder |
Shipping and Storage
| Store Temp | -20°C |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Feng C., Sun Y., PI3Kβ inhibitor TGX221 selectively inhibits renal cell carcinoma cells with both VHL and SETD2 mutations and links multiple pathways. Sci Rep. 5:9465 (2015). PMID: 25853938.
Yang X., Yang J., TGX-221 inhibits proliferation and induces apoptosis in human glioblastoma cells. Oncol Rep. 38(5):2836-2842. PMID: 29048665.