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Tianeptine

Tianeptine

Product ID T3202
Cas No. 66981-73-5
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $102.70 In stock
50 mg $355.00 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tianeptine is an agonist at μORs and δORs as well as a potentiator at D2 and D3 DA receptors. Tianeptine exhibits neuromodulatory, antidepressant, anxiolytic, analgesic, anticonvulsant, and anti-inflammatory activities, although its mechanism of action is not well understood. In vitro, tianeptine inhibits LPS-induced inflammation and activation of microglia; is also decreases pro-inflammatory cytokine release, ROS release, and NF-κB activation. Clinically, this compound improves anxiety symptoms, neurocognitive function, and memory. Tianeptine also attenuates mechanical allodynia, an effect that may be mediated by 5-HT7 receptors.

Product Info

Cas No.

66981-73-5

Purity

≥98%

Formula

C21H25ClN2O4S

Formula Wt.

436.95

Chemical Name

(1)-7-((3-Chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoic acid S,S-dioxide

IUPAC Name

7-[(3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid

Synonym

Tianeptine Acid; 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T3202 MSDS PDF

Info Sheet

T3202 Info Sheet PDF

References

Slusarczyk J, Trojan E, Glombik K, et al. Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve Toll-like receptor-related pathways. J Neurochem. 2015 Dec 7. [Epub ahead of print]. PMID: 26640965.

Yoo I, Woo JM, Lee SH, et al. Influence of anxiety symptoms on improvement of neurocognitive functions in patients with major depressive disorder: A 12-week, multicenter, randomized trial of tianeptine versus escitalopram, the CAMPION study. J Affect Disord. 2015 Oct 1;185:24-30. PMID: 26142691.

Lin H, Heo BH, Kim WM, et al. Antiallodynic effect of tianeptine via modulation of the 5-HT7 receptor of GABAergic interneurons in the spinal cord of neuropathic rats. Neurosci Lett. 2015 Jun 26;598:91-5. PMID: 25982324.

Cooper CM, Whiting DA, Cowen PJ, et al. Tianeptine in an experimental medicine model of antidepressant action. J Psychopharmacol. 2015 May;29(5):582-90. PMID: 25759404.

Custom Order

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