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Tigecycline

Tigecycline

Product ID T3324
Cas No. 220620-09-7
Purity ≥98%
Product Unit SizeCostQuantityStock
25 mg $90.30 In stock
100 mg $188.70 In stock
250 mg $352.30 In stock
1 g $1,006.20 In stock
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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tigecycline is a glycylcycline antibiotic that displays antibacterial activity against gram positive and gram negative bacteria and also exhibits some neuroprotective and anti-inflammatory benefit as well. The antibacterial activity of tigecycline is due to its binding in the A site of the 30S ribosome and resulting inhibition of prokaryotic protein synthesis. In neuronal cells administered LPS, tigecycline prevents release of NF-κB, TNF-α, IL-1β, cytochrome C, decreases levels of NO and Bad, increases expression of Bcl-2, and decreases activity of caspase-3.

Product Info

Cas No.

220620-09-7

Purity

≥98%

Formula

C29H39N5O8

Formula Wt.

585.65

Chemical Name

N-[(5aR,6aS,7S,9Z,10aS)-9-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5,5a,6,6a,7,8,9,10,10a,11-decahydrotetracen-2-yl]-2-(tert-butylamino)acetamide

IUPAC Name

(4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide

Synonym

Tygacil

Solubility

DMSO (~3 mg/ml with warming)

Appearance

Orange Powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

T3324 MSDS PDF

Info Sheet

T3324 Info Sheet PDF

References

Yagnik RM, Benzeroual KE. Tigecycline prevents LPS-induced release of pro-inflammatory and apoptotic mediators in neuronal cells. Toxicol In Vitro. 2013 Mar;27(2):686-93. PMID: 23200736.

da Silva LM, Nunes Salgado HR. Tigecycline: a review of properties, applications, and analytical methods. Ther Drug Monit. 2010 Jun;32(3):282-8. PMID: 20431506.

Olson MW, Ruzin A, Feyfant E, et al. Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrob Agents Chemother. 2006 Jun;50(6):2156-66. PMID: 16723578.

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