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Tirapazamine

Tirapazamine

Product ID T3468
Cas No. 27314-97-2
Purity ≥98%
Product Unit SizeCostQuantityStock
10 mg $91.00 In stock
25 mg $182.50 In stock
100 mg $510.50 In stock
Bulk Quote

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  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
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  • Downloads
  • References
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Description

Tirapazamine is an anticancer chemotherapeutic compound currently in clinical trials co-administered with cisplatin or radiation as a potential treatment for several cancers. Tirapazamine inhibits DNA topoisomerase IIα and modulates replication protein A (RPA), inhibiting DNA replication. Tirapazamine also forms DNA damaging free radicals, inducing single- and double-stranded DNA breaks. Additionally, tirapazamine inhibits expression of HIF-1α, potentially through modulation of eukaryotic initiation factor eIF2α phosphorylation. This compound induces apoptosis in neuroblastoma cells, decreasing the mitochondrial membrane potential and levels of glutathione; this effect may be p53-dependent.

Product Info

Cas No.

27314-97-2

Purity

≥98%

Formula

C7H6N4O2

Formula Wt.

178.15

IUPAC Name

4-hydroxy-1-oxido-1,2,4-benzotriazin-1-ium-3-imine

Synonym

SR 4233

Appearance

Orange-red crystalline powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

T3468 MSDS PDF

Info Sheet

T3468 Info Sheet PDF

References

Zhang J, Cao J, Weng Q, et al. Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway. PLoS One. 2010 Nov 9;5(11):e13910. PMID: 21085474.

Yang B, Reynolds CP. Tirapazamine cytotoxicity for neuroblastoma is p53 dependent. Clin Cancer Res. 2005 Apr 1;11(7):2774-80. PMID: 15814660.

Peters KB, Wang H, Brown JM, et al. Inhibition of DNA replication by tirapazamine. Cancer Res. 2001 Jul 15;61(14):5425-31. PMID: 11454687.

Brown JM, Wang LH. Tirapazamine: laboratory data relevant to clinical activity. Anticancer Drug Des. 1998 Sep;13(6):529-39. PMID: 9755717.

Custom Order

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