LKT Labs

Biochemicals for Life Science Research

Torsemide

Product ID T5968
Cas No. 56211-40-6
Purity ≥99%
Product Unit SizeCostQuantityStock
100 mg $84.90 In stock
250 mg $170.00 In stock
1 g $509.80 In stock
Bulk Quote
Browse Wishlist

Quicklinks

Description

Torsemide is a pyridine-sulfonyl urea loop diuretic known for its antihypertensive and cardioprotective activities. This compound acts as a competitive inhibitor of the Na+-K+-2Cl- symporter in the loop of Henle by binding directly to the Cl- binding site; this inhibition prevents reabsorption of Na+, Cl-, Mg2+, and Ca2+, resulting in a decrease in blood volume and pressure. Torsemide treats edema, hypertension, and congestive heart failure, attenuating left ventricular cardiac remodeling. This compound also inhibits aldosterone secretion and ATPase activity of HSP90.

Product Info

Cas No.

56211-40-6
Purity

≥99%
Formula

C16H20N4O3S
Formula Wt.

348.42
Chemical Name

N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
IUPAC Name

1-[4-(3-methylanilino)pyridin-3-yl]sulfonyl-3-propan-2-ylurea
Synonym

Torasemide
Solubility

DMSO 18 mg/mL Water Insoluble Ethanol Insoluble
Appearance

White to off white powder

Shipping and Storage

Store Temp

Ambient
Ship Temp

Ambient

Downloads

MSDS

T5968 MSDS PDF
Info Sheet

T5968 Info Sheet PDF

References

Sheikha GA, Al-Sha'er MA, Taha MO. Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation. J Enzyme Inhib Med Chem. 2011 Oct;26(5):603-9. PMID: 21190426.

Kasama S, Toyama T, Hatori T, et al. Effects of torasemide on cardiac sympathetic nerve activity and left ventricular remodelling in patients with congestive heart failure. Heart. 2006 Oct;92(10):1434-40. PMID: 16621879.

Goodfriend TL, Ball DL, Oelkers W, et al. Torsemide inhibits aldosterone secretion in vitro. Life Sci. 1998;63(3):PL45-50. PMID: 9698054.

Lupinacci L, Puschett JB. An examination of the site and mechanism of action of torasemide in man. J Clin Pharmacol. 1988 May;28(5):441-7. PMID: 3392242.

Recasens M, Pin JP, Bockaert J. Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes. Neurosci Lett. 1987 Feb 24;74(2):211-6. PMID: 2883610.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.