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Trimethoprim is an antibiotic that inhibits dihydrofolate reductase, acting as an anti-folate. Trimethoprim exhibits antibacterial activity against both gram positive and gram negative bacteria and is clinically used to treat urinary tract infections.
| Cas No. | 738-70-5 |
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| Purity | ≥98% |
| Formula | C14H18N4O3 |
| Formula Wt. | 290.32 |
| Chemical Name | 5-[(3,4,5-Trimethoxyphenyl)methyl]-2,4- pyrimidinediamine |
| IUPAC Name | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| Synonym | Instalac, Monotrim, Proloprim, Trimopan, Trimpex, Wellcoprim |
| Melting Point | 199-203°C |
| Solubility | Soluble in DMAC, or benzyl alcohol. Slightly soluble in propylene glycol, chloroform, methanol and water. |
| Appearance | White or yellowish white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Singh P, Kaur M, Sachdeva S. Mechanism inspired development of rationally designed dihydrofolate reductase inhibitors as anticancer agents. J Med Chem. 2012 Jul 26;55(14):6381-90. PMID: 22734697.
Sangurdekar DP, Zhang Z, Khodursky AB. The association of DNA damage response and nucleotide level modulation with the antibacterial mechanism of the anti-folate drug trimethoprim. BMC Genomics. 2011 Nov 28;12:583. PMID: 22122981.
Brogden RN, Carmine AA, Heel RC, et al. Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections. Drugs. 1982 Jun;23(6):405-30. PMID: 7049657.
Ho YB, Zakaria MP, Latif PA, Saari N. Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia. Sci Total Environ. 2014 Aug 1;488-489:261-267. PMID: 24836135.