LKT Labs

Biochemicals for Life Science Research

Tropodithietic Acid

Tropodithietic Acid

Product ID T698579
Cas No. 750590-18-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $240.00 In stock
5 mg $962.00 In stock
Bulk Quote

Quicklinks

Description

Tropodithietic acid is an antibiotic produced by various marine proteobacteria. Tropodithietic acid has been found to have the same activity as endogenous N-acyl-homoserine lactones and can trigger quorum-sensing in marine bacterium. Furthermore, it has been shown that long-term exposure to tropodithietic acid does not result in antibacterial resistant or tolerant strains. In addition, screening of the NCI-60 human tumor cell lines showed tropodithietic acid to have strong growth-inhibitory anticancer activity.

Product Info

Cas No.

750590-18-2
Purity

≥99%
Formula

C8H4O3S2
Formula Wt.

212.24
Chemical Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
IUPAC Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
Synonym

TDA
Solubility

Soluble in polar organic solvents, such as DMSO, Methanol, Acetone
Appearance

Orange powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T698579 MSDS PDF
Info Sheet

T698579 Info Sheet PDF

References

Beyersmann PG, Tomasch J, Son K, et al. Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens. Sci Rep. 2017 Apr 7;7(1):730. PMID: 28389641.

Rasmussen BB, Grotkjaer T, D’Alvise PW, et al. Vibrio anguillarum is genetically and phenotypically unaffected by long-term continuous exposure to the antibacterial compound tropodithietic acid. Appl Environ Microbiol. 2016 Jul 15;82(15):4802-4810. PMID: 27235441.

Wilson MZ, Wang R, Gitai Z, et al. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the gamma-glutamyl cycle as a proton sink. Proc Natl Acad Sci USA. 2016 Feb 9;113(6):1630-1635. PMID: 26802120.

Porsby CH, Webber MA, Nielsen KF, et al. Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select. Antimicrob Agents Chemother. 2011 Apr;55(4):1332-1337. PMID: 21263047.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • I5440

    INK128

    mTOR inhibitor.

    ≥99%
  • A2658

    Agomelatine

    Melatonin analog; MT1/2 agonist, 5-HT2C antagon...

    ≥98%
  • R5772

    Rosiglitazone Maleate

    Thiazolidinedione; PPARγ agonist.

    ≥98%
  • L1735

    Levitide

    Antimicrobial peptide found in amphibians.

    ≥95%
  • T5605

    Tobramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • P200099

    PF-06939999

    PRMT5 inhibitor

    ≥98%
  • S9755

    (R)-Synephrine

    Synephrine is an endogenous alkaloid.

    ≥98%
  • M002698

    M2698

    Dual inhibitor of p70S6K and Akt.

    ≥99%
  • A971334

    Azilsartan

    Sartan

    ≥98%
  • A706840

    ARV-825

    Degrades of BET proteins.

    ≥99%
  • A5228

    Angiogenin

    Small protein, cleaves RNA.

    ≥98%
  • C0021

    Cafestol Acetate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • T564091

    β-Tocopherol

    Vitamin E component

    ≥98%
  • T2934

    Thiamphenicol Palmitate

    Chloramphenicol derivative; protein translation...

    ≥98%
  • R2711

    Recombinant HCV-Core Antigens

    Recombinant HIV core protein antigen fragment.<...

    ≥95%
  • I527211

    Infigratinib Phosphate

    FGFR inhibitor.

    ≥98%
  • A5217

    trans-Anethole

    Phenylpropene derivative found in essential oil...

    ≥98%
  • P8117

    Puerarin, High Purity

    Isoflavone found in Pueraria; 5-HT2C and GABA-A...

    ≥99%
  • O456505

    Olmutinib

    EGFR inhibitor.

    ≥98%
  • S0459

    SB-590885

    B-Raf inhibitor.

    ≥97%