LKT Labs

Biochemicals for Life Science Research

Tropodithietic Acid

Tropodithietic Acid

Product ID T698579
Cas No. 750590-18-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $240.00 In stock
5 mg $962.00 In stock
Bulk Quote

Quicklinks

Description

Tropodithietic acid is an antibiotic produced by various marine proteobacteria. Tropodithietic acid has been found to have the same activity as endogenous N-acyl-homoserine lactones and can trigger quorum-sensing in marine bacterium. Furthermore, it has been shown that long-term exposure to tropodithietic acid does not result in antibacterial resistant or tolerant strains. In addition, screening of the NCI-60 human tumor cell lines showed tropodithietic acid to have strong growth-inhibitory anticancer activity.

Product Info

Cas No.

750590-18-2
Purity

≥99%
Formula

C8H4O3S2
Formula Wt.

212.24
Chemical Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
IUPAC Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
Synonym

TDA
Solubility

Soluble in polar organic solvents, such as DMSO, Methanol, Acetone
Appearance

Orange powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T698579 MSDS PDF
Info Sheet

T698579 Info Sheet PDF

References

Beyersmann PG, Tomasch J, Son K, et al. Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens. Sci Rep. 2017 Apr 7;7(1):730. PMID: 28389641.

Rasmussen BB, Grotkjaer T, D’Alvise PW, et al. Vibrio anguillarum is genetically and phenotypically unaffected by long-term continuous exposure to the antibacterial compound tropodithietic acid. Appl Environ Microbiol. 2016 Jul 15;82(15):4802-4810. PMID: 27235441.

Wilson MZ, Wang R, Gitai Z, et al. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the gamma-glutamyl cycle as a proton sink. Proc Natl Acad Sci USA. 2016 Feb 9;113(6):1630-1635. PMID: 26802120.

Porsby CH, Webber MA, Nielsen KF, et al. Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select. Antimicrob Agents Chemother. 2011 Apr;55(4):1332-1337. PMID: 21263047.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • G691343

    Griseofulvin

    Fungistatic

    ≥98%
  • L3453

    Linezolid

    Oxazolidinone; protein synthesis inhibitor.

    ≥99%
  • T5769

    Toremifene Base

    SERM, androgen modulator.

    ≥98%
  • P005095

    N-Debenzoylpaclitaxel

    Paclitaxel derivative

    ≥95%
  • A5160

    Ampicillin Trihydrate

    β-lactam; transpeptidase inhibitor.

    ≥97%
  • Z7477

    ZSTK474

    PI3K inhibitor.

    ≥98%
  • P2410

    Phenethyl Dimethyl Caffeate

    Caffeic acid derivative.

    ≥98%
  • H9611

    Hydrocortisone

    Endogenous steroid hormone involved in stress s...

    ≥98%
  • E2002

    Efaroxan Hydrochloride

    α2-adrenergic and imidazoline-1 antagonist, AT...

    ≥99%
  • D5792

    Doxofylline

    Xanthine derivative; PDE inhibitor.

    ≥98%
  • P1200

    PD-184352

    MEK1/2 and Raf inhibitor.

    ≥98%
  • H9812

    5-Hydroxytryptophol

    Serotonin/melatonin analog found in various pla...

    ≥98%
  • M9643

    Myelin Basic Protein (1-11), human

    Peptide antigen fragment

    ≥95%
  • E5201

    Enalapril Maleate

    ACE inhibitor.

    ≥98%
  • R3584

    Rivaroxaban

    Oxazolidone derivative; Factor Xa inhibitor.

    ≥98%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • C0175

    Carbetocin Acetate

    Peptide, oxytocin analog; potential OXTR agonis...

    ≥95%
  • L283080

    LHC-165

    TLR7 agonist

    ≥99%
  • I4934

    Imipenem Monohydrate

    Carbapenem β-lactam; penicillin binding protei...

    ≥98%
  • C3449

    Clodronate Disodium Tetrahydrate

    Non-nitrogen bisphosphonate; mitochondrial ATP/...

    ≥98%