LKT Labs

Biochemicals for Life Science Research

Tropodithietic Acid

Tropodithietic Acid

Product ID T698579
Cas No. 750590-18-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $240.30 In stock
5 mg $961.60 In stock
Bulk Quote

Quicklinks

Description

Tropodithietic acid is an antibiotic produced by various marine proteobacteria. Tropodithietic acid has been found to have the same activity as endogenous N-acyl-homoserine lactones and can trigger quorum-sensing in marine bacterium. Furthermore, it has been shown that long-term exposure to tropodithietic acid does not result in antibacterial resistant or tolerant strains. In addition, screening of the NCI-60 human tumor cell lines showed tropodithietic acid to have strong growth-inhibitory anticancer activity.

Product Info

Cas No.

750590-18-2
Purity

≥99%
Formula

C8H4O3S2
Formula Wt.

212.24
Chemical Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
IUPAC Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
Synonym

TDA
Solubility

Soluble in polar organic solvents, such as DMSO, Methanol, Acetone
Appearance

Orange powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T698579 MSDS PDF
Info Sheet

T698579 Info Sheet PDF

References

Beyersmann PG, Tomasch J, Son K, et al. Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens. Sci Rep. 2017 Apr 7;7(1):730. PMID: 28389641.

Rasmussen BB, Grotkjaer T, D’Alvise PW, et al. Vibrio anguillarum is genetically and phenotypically unaffected by long-term continuous exposure to the antibacterial compound tropodithietic acid. Appl Environ Microbiol. 2016 Jul 15;82(15):4802-4810. PMID: 27235441.

Wilson MZ, Wang R, Gitai Z, et al. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the gamma-glutamyl cycle as a proton sink. Proc Natl Acad Sci USA. 2016 Feb 9;113(6):1630-1635. PMID: 26802120.

Porsby CH, Webber MA, Nielsen KF, et al. Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select. Antimicrob Agents Chemother. 2011 Apr;55(4):1332-1337. PMID: 21263047.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • S8251

    Sulfluramid

    Perfluorinated insecticide.

    ≥95%
  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • E6880

    Erucin

    Isothiocyanate found in cruciferous vegetables,...

    ≥98%
  • N1986

    Neuropeptide Y, human/rat

    Endogenous peptide neurotransmitter, involved i...

    ≥95%
  • V3252

    Vinorelbine Ditartrate

    Semi-synthetic vinca alkaloid from Catharanthus...

    ≥98%
  • C167200

    Cefazolin

    Cephalosporin analogue

    ≥98%
  • T1853

    Tenovin-6

    SIRT1/2 inhibitor, indirect p53 activator.

    ≥98%
  • F3207

    Fibronectin CS-1 Peptide

    Peptide; α4β1 integrin activator.

    ≥95%
  • M4454

    MLN-4924

    Nedd8-activating enzyme inhibitor.

    ≥99%
  • S8012

    [Sar9]-Substance P

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • D3374

    Disulfiram

    Aldehyde dehydrogenase, 26S proteasome, MGMT in...

    ≥98%
  • D3447

    Diltiazem Hydrochloride

    Benzothiazepine; L-type Ca2+ channel blocker, p...

    ≥98%
  • C577524

    Concanamycin A

    Macrolide lactone antibiotic.

    ≥98%
  • B5000

    BMS-911543

    JAK2 inhibitor.

    ≥99%
  • T0152

    Tandutinib

    FLT3, PDGFR, c-Kit inhibitor.

    ≥98%
  • G3554

    Ginsenoside Rb3

    Triterpene saponin found in species of Panax.

    ≥98%
  • X4402

    XL-147

    Dual inhibitor of PI3K and mTOR.

    ≥98%
  • A985120

    AZD-0156

    Inhibitor of ATM.

    ≥98%
  • V174459

    Velpatasvir

    Inhibits NS5A

    ≥99%
  • C451338

    Clioquinol

    Antifungal agent with neuroprotective activity....

    ≥98%