LKT Labs

Biochemicals for Life Science Research

Tropodithietic Acid

Tropodithietic Acid

Product ID T698579
Cas No. 750590-18-2
Purity ≥99%
Product Unit SizeCostQuantityStock
1 mg $240.00 In stock
5 mg $962.00 In stock
Bulk Quote

Quicklinks

Description

Tropodithietic acid is an antibiotic produced by various marine proteobacteria. Tropodithietic acid has been found to have the same activity as endogenous N-acyl-homoserine lactones and can trigger quorum-sensing in marine bacterium. Furthermore, it has been shown that long-term exposure to tropodithietic acid does not result in antibacterial resistant or tolerant strains. In addition, screening of the NCI-60 human tumor cell lines showed tropodithietic acid to have strong growth-inhibitory anticancer activity.

Product Info

Cas No.

750590-18-2
Purity

≥99%
Formula

C8H4O3S2
Formula Wt.

212.24
Chemical Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
IUPAC Name

3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid
Synonym

TDA
Solubility

Soluble in polar organic solvents, such as DMSO, Methanol, Acetone
Appearance

Orange powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

T698579 MSDS PDF
Info Sheet

T698579 Info Sheet PDF

References

Beyersmann PG, Tomasch J, Son K, et al. Dual function of tropodithietic acid as antibiotic and signaling molecule in global gene regulation of the probiotic bacterium Phaeobacter inhibens. Sci Rep. 2017 Apr 7;7(1):730. PMID: 28389641.

Rasmussen BB, Grotkjaer T, D’Alvise PW, et al. Vibrio anguillarum is genetically and phenotypically unaffected by long-term continuous exposure to the antibacterial compound tropodithietic acid. Appl Environ Microbiol. 2016 Jul 15;82(15):4802-4810. PMID: 27235441.

Wilson MZ, Wang R, Gitai Z, et al. Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the gamma-glutamyl cycle as a proton sink. Proc Natl Acad Sci USA. 2016 Feb 9;113(6):1630-1635. PMID: 26802120.

Porsby CH, Webber MA, Nielsen KF, et al. Resistance and tolerance to tropodithietic acid, an antimicrobial in aquaculture, is hard to select. Antimicrob Agents Chemother. 2011 Apr;55(4):1332-1337. PMID: 21263047.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E7356

    Esomeprazole Magnesium Trihydrate

    S-isomer of omeprazole; H+/K+ ATPase inhibitor....

    ≥99%
  • A0802

    Acarbose

    α-glucosidase inhibitor.

    ≥98%
  • G0144

    Galactosamine Hydrochloride

    Galactose-derived hexosamine sugar, component o...

    ≥98%
  • J889280

    JWH 015

    Cannabinoid receptor 2 selective agonist.

    ≥98%
  • C0351

    Carprofen

    NSAID; COX-2 inhibitor.

    ≥98%
  • P1952

    Penitrem A

    Neuroactive mycotoxin produced by Penicillum an...

    ≥97%
  • P5745

    Polygalic Acid

    Saponin found in Polygala.

    ≥97%
  • A2052

    Aflatoxin M1

    Mycotoxin produced by species of Aspergillus; D...

    ≥98%
  • T162051

    Tebipenem

    Broad-spectrum antibiotic

    ≥99%
  • T5060

    TMP-269

    HDAC inhibitor.

    ≥98%
  • C104761

    CCT-196969

    pan-Raf inhibitor.

    ≥98%
  • G1650

    Geniposide

    Iridoid glycoside found in Gardenia.

    ≥98%
  • C084099

    CCCP

    Efflux pump inhibitor

    ≥99%
  • M0009

    Macitentan

    ET-A/B antagonist.

    ≥99%
  • I0518

    I-BET-762

    BRD inhibitor.

    ≥98%
  • L9610

    Lycorine Hydrochloride

    Alkaloid found in plants in the Amaryllidaceae ...

    ≥98%
  • C0022

    Cafestol Palmitate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥97%
  • A4617

    Aloe Emodin

    Anthraquinone found in aloe; CTFR Cl- channel a...

    ≥98%
  • A9713

    AZD-3514

    Androgen receptor downregulator.

    ≥98%
  • L8262

    Lupinine

    Alkaloid found in species of Loranthus, Calia, ...

    ≥98%