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Urotensin II, human

Product ID U6959
Cas No. 251293-28-4
Purity ≥95%
Product Unit SizeCostQuantityStock
0.5 mg $252.20 Please Inquire
1 mg $430.10 Please Inquire
2.5 mg $756.90 Please Inquire
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  • Description
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Description

Urotensin II is a peptide ligand that binds the urotensin II (UT) receptor and can be used as a biomarker for hypertension and type 2 diabetes. Urotensin II increases expression of IL-6, IL-1β, VCAM-1, and tissue factor in vitro, exhibiting pro-inflammatory activity. Urotensin II also inhibits glucose transport through modulation of NADPH oxidase signaling, which increases levels of ROS and decreases phosphorylation of Akt, ERK1/2, and p38 MAPK. Additionally, urotensin II can induce apoptosis in cardiac tissue cells and can induce relaxation in smooth muscle cells.

Product Info

Cas No.

251293-28-4

Purity

≥95%

Formula

C64H85N13O18S2

Formula Wt.

1388.6

Solubility

Soluble in water (1 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

U6959 MSDS PDF

Info Sheet

U6959 Info Sheet PDF

References

Peng H, Zhang M, Cai X, et al. Association between Human Urotensin II and Essential Hypertension-A 1:1 Matched Case-Control Study. PLoS One. 2013 Dec 10;8(12):e81764. PMID: 24339964.

Wang HX, Wu XR, Yang H, et al. Urotensin II inhibits skeletal muscle glucose transport signaling pathways via the NADPH oxidase pathway. PLoS One. 2013 Oct 8;8(10):e76796. PMID: 24116164.

Park SL, Lee BK, Kim YA, et al. Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Induced by Urotensin II in Human Vascular Endothelial Cells. Biomol Ther (Seoul). 2013 Jul 30;21(4):277-83. PMID: 24244812.

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