Description
Velpatasvir is an antiviral small molecule that prevents viral replication by inhibiting non-structural protein 5A (NS5A).
Velpatasvir
Product ID V174459
Cas No. 1377049-84-7
Purity ≥99%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 1377049-84-7 |
|---|---|
| Purity | ≥99% |
| Formula | C49H54N8O8 |
| Formula Wt. | 883.00 |
| Chemical Name | Methyl [(2S)-1-[(2S,5S)-2-[9-[2-[(2S,4S)-1-[(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate |
| IUPAC Name | methyl N-[(1R)-2-[(2S,4S)-2-[5-[6-[(2S,5S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]-5-methylpyrrolidin-2-yl]-21-oxa-5,7-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1(13),2,4(8),5,9,11,14(19),15,17-nonaen-17-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate |
| Synonym | GS-5816, UNII-KCU0C7RS7Z, GS5816 |
| Solubility | Soluble in Ethanol and DMSO. Insoluble in water. |
| Appearance | White to off white powder |
Shipping and Storage
| Store Temp | Ambient |
|---|---|
| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Ramirez S, Fernandez-Antunez C, Mikkelsen L, et al. Cell culture studies of the efficacy and barrier to resistance of sofosbuvir-velpatasvir and glecaprevir-pibrentasvir against hepatitis C virus genotypes 2a, 2b, and 2c. Antimicrob Agents Chemother. 2020 Feb 21;64(3):e01888. PMID: 31818814.
Pham L, Ramirez S, Gottwein J, et al. HCV genotype 6a escape from and resistance to velpatasvir, pibrentasvir, and sofosbuvir in robust infectious cell culture models. Gastroenterology. 2018 Jun;154(8):2194-2208. PMID: 29454794.