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Vinpocetine

Vinpocetine

Product ID V3455
Cas No. 42971-09-5
Purity ≥98%
Product Unit SizeCostQuantityStock
20 mg $149.80 In stock
100 mg $426.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Vinpocetine is a synthetic analogue of the alkaloid apovincamine, which is isolated from the lesser periwinkle plant. It has been shown to inhibit lipopolysaccharide-induced lung inflammation in mice by targeting nuclear factor kappa B activation. Furthermore, it is known to be a safe nootropic agent and is commonly used to enhance memory and to treat various neurological diseases.

Product Info

Cas No.

42971-09-5

Purity

≥98%

Formula

C22H26N2O2

Formula Wt.

350.46

Chemical Name

ethyl (15S,19S)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18),16-pentaene-17-carboxylate

IUPAC Name

Ethyl (3α,16α)-eburnamenine-14-carboxylate

Synonym

Cavinton, Ceractin, Apovincaminic acid ethyl ester

Melting Point

147-149°C

Solubility

Soluble in DMSO (5 mg/ml), ethanol (15 mg/ml) and DMF (3 mg/m).

Appearance

White powder

Shipping and Storage

Store Temp

Ambient

Ship Temp

Ambient

Downloads

MSDS

V3455 MSDS PDF

Info Sheet

V3455 Info Sheet PDF

References

Hagiwara M, Endo T, Hidaka H. Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle. Biochem Pharmacol. 1984 Feb 1;33(3):453-7. PMID: 6322804

Molnár P1, Erdö SL. Vinpocetine is as potent as phenytoin to block voltage-gated Na+ channels in rat cortical neurons. Eur J Pharmacol. 1995 Feb 6;273(3):303-6. PMID: 7737339

Gómez CD1, Buijs RM, Sitges M. The anti-seizure drugs vinpocetine and carbamazepine, but not valproic acid, reduce inflammatory IL-1β and TNF-α expression in rat hippocampus. J Neurochem. 2014 Sep;130(6):770-9. doi: 10.1111/jnc.12784. Epub 2014 Jun 27. PMID: 24903676

Wang H1, Zhang K2, Zhao L3, Tang J3, Gao L3, Wei Z3. Anti-inflammatory effects of vinpocetine on the functional expression of nuclear factor-kappa B and tumor necrosis factor-alpha in a rat model of cerebral ischemia-reperfusion injury. Neurosci Lett. 2014 Apr 30;566:247-51. doi: 10.1016/j.neulet.2014.02.045. Epub 2014 Mar 2. PMID: 24598438

Zhao YY1, Yu JZ, Li QY, Ma CG, Lu CZ, Xiao BG. TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation. Neuron Glia Biol. 2011 May;7(2-4):187-97. doi: 10.1017/S1740925X12000129. Epub 2012 Jul 6. PMID: 22874716

Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Zarpelon AC, et al. Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines, and NF-kB. Chem Biol Interact. 2015 Jul 25;237:9-17. PMID: 25980587

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