LKT Labs

Biochemicals for Life Science Research

Vitexin

Vitexin

Product ID V344766
Cas No. 3681-93-4
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $45.30 In stock
25 mg $147.20 In stock
100 mg $420.60 In stock
Bulk Quote

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Description

Vitexin is a naturally occurring flavonoid found in hawthorn leaves. Treatment of diabetic rats with vitexin has been found to result in pancreatic islet regeneration, prevention of beta-cell destruction, and suppression of lipopolysaccharide-induced release of HMGB1 protein. Pretreatment of neonatal C57BL/6 mice with vitexin provided neuroprotection against hypoxic-ischemic brain injury. In addition, vitexin is has shown anti-oxidant, anti-inflammatory, analgesic, and antitumor activities in several cancer models and cell lines. It has been found to impact the JNK MAPK signaling pathway to inhibit growth of hepatocellular carcinoma cells.

Product Info

Cas No.

3681-93-4
Purity

≥98%
Formula

C21H20O10
Formula Wt.

432.38
Chemical Name

5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
IUPAC Name

5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
Synonym

Apigenin-8-C-glucoside, Vitxein
Solubility

Soluble in water and in DMSO
Appearance

Off white to yellow

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

V344766 MSDS PDF
Info Sheet

V344766 Info Sheet PDF

References

Nurdiana S, Goh YM, Ahmad H, et al. Changes in pancreatic histology, insulin secretion and oxidative status in diabetic rats following treatment with Ficus deltoidea and vitexin. BMC Complement Altern Med. 2017 Jun 2;17(1):290. PMID: 28576138.

Wang F, Yin J, Ma Y, et al. Vitexin alleviates lipopolysaccharide-induced islet cell injury by inhibiting HMGB1 release. Mol Med Rep. 2017 Mar;15(3):1079-1086. PMID: 28098903.

Min JW, Kong WL, Han S, et al. Vitexin protects against hypoxic-ischemic injury via inhibiting Ca2+/Calmodulin-dependent protein kinase II and apoptosis signaling in the neonatal mouse brain. Oncotarget. 2017 Apr 11;8(15):25513-25524. PMID: 28424420.

He JD, Wang Z, Li SP, et al. Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway. Oncotarget. 2016 Dec 20;7(51):84520-84532. PMID: 27588401.

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