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Xenopsin

Xenopsin

Product ID X1753
Cas No. 51827-01-1
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $81.70 In stock
2 mg $138.90 In stock
5 mg $245.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Xenopsin is a neurotensin-related octapeptide hormone originally found in amphibians. Xenopsin exhibits anti-inflammatory activity, decreasing vascular leakage in animal models of edema/inflammation. Xenopsin also increases firing rates of dopaminergic neurons. In ileal smooth muscle cells, xenopsin induces relaxation. Xenopsin also increases insulin release in pancreatic β-cells and stimulates meal-dependent exocrine pancreatic secretion.

Product Info

Cas No.

51827-01-1

Purity

≥95%

Formula

C47H73N13O10

Formula Wt.

980.19

IUPAC Name

(2S)-2-[[(3S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-2-[[2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]acetyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid

Solubility

Soluble in DMSO, water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

X1753 MSDS PDF

Info Sheet

X1753 Info Sheet PDF

References

Zahid OK, Mechkarska M, Ojo OO, et al. Caerulein-and xenopsin-related peptides with insulin-releasing activities from skin secretions of the clawed frogs, Xenopus borealis and Xenopus amieti (Pipidae). Gen Comp Endocrinol. 2011 Jun 1;172(2):314-20. PMID: 21458457.

Clemens A, Katsoulis S, Nustede R, et al. Relaxant effect of xenin on rat ileum is mediated by apamin-sensitive neurotensin-type receptors. Am J Physiol. 1997 Jan;272(1 Pt 1):G190-6. PMID: 9038893.

Gao GC, Wei ET. Xenopsin, neurotensin, neurotensin(8-13) and N-acetyl-neurotensin(8-13) inhibit vascular leakage in rats after tissue injury. J Pharmacol Exp Ther. 1993 May;265(2):619-25. PMID: 8496813.

Feurle GE, Hamscher G, Kusiek R, et al. Identification of xenin, a xenopsin-related peptide, in the human gastric mucosa and its effect on exocrine pancreatic secretion. J Biol Chem. 1992 Nov 5;267(31):22305-9. PMID: 1429581.

Pozza MF, Küng E, Bischoff S, et al. The neurotensin analog xenopsin excites nigral dopamine neurons. Eur J Pharmacol. 1988 Jan 19;145(3):341-3. PMID: 3350051.

Custom Order

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