• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
XL-147

XL-147

Product ID X4402
Cas No. 934526-89-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $58.50 In stock
5 mg $84.30 In stock
10 mg $162.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

XL-147 is an inhibitor of PI3K that is currently in clinical trials as a potential treatment for cancers with solid tumors. XL-147 exhibits anticancer chemotherapeutic properties, inhibiting tumor growth in animal models of acute lymphocytic leukemia (ALL). XL-147 is a dual inhibitor of PI3K and mTOR. It exhibits higher efficacy than either sole PI3K or mTOR inhibition in models of prostate cancer.

Product Info

Cas No.

934526-89-3

Purity

≥98%

Formula

C25H25ClN6O4S

Formula Wt.

541.02

IUPAC Name

N-[3-(2,1,3-benzothiadiazol-5-ylamino)quinoxalin-2-yl]-4-methylbenzenesulfonamide

Synonym

Pilaralisib, SAR245408

Solubility

DMSO 3 mg/mL (6.68 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

X4402 MSDS PDF

Info Sheet

X4402 Info Sheet PDF

References

Shapiro GI, Rodon J, Bedell C, et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors. Clin Cancer Res. 2014 Jan 1;20(1):233-45. PMID: 24166903.

Reynolds CP, Kang MH, Carol H, et al. Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013 May;60(5):791-8. PMID: 23002019.

Gravina G., Mancini A., Dual PI3K/mTOR inhibitor, XL765 (SAR245409), shows superior effects to sole PI3K [XL147 (SAR245408)] or mTOR [rapamycin] inhibition in prostate cancer cell models. 37(1):341-51 (2016). PMID: 26219891.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%
  • N3478

    Nitrendipine

    Calcium channel blocker.

    ≥98%
  • V014463

    Valsartan Methyl Ester

    Valsartan impurity

    ≥98%
  • A9617

    Azelnidipine

    Dihydropyridine; L-type Ca2+ channel blocker. &...
    ≥98%
  • A5057

    Amoxicillin

    β-lactam; penicillin binding protein inhibitor. ...
    ≥99%
  • V574451

    Volitinib

    c-Met inhibitor.

    ≥98%
  • G7200

    GS-967

    Na+ channel blocker.

    ≥98%
  • M704789

    MRTX1133

    KRAS inhibitor

    ≥98%
  • P0008

    Pituitary Adenylate Cyclase-activating Peptide (6-38), human/sheep/rat

    Endogenous peptide, involved in paracrine and a...

    ≥95%
  • S1058

    Scopolamine N-butylbromide

    Tropane alkaloid found in Solanaceae plants; M1...

    ≥98%
  • S176481

    Semaglutide

    GLP-1 agonist

    ≥95%
  • B5072

    BMS-754807

    InsR and IGF-1R inhibitor.

    ≥99%
  • A985130

    AZD-7762

    CHK1 inhibitor.

    ≥98%
  • M185777

    4-(Methylsulfinyl) butylamine

    ≥99%
  • M4455

    MLN-2238

    Proteasome inhibitor, miR33b modulator.

    ≥95%
  • A4444

    L-Alliin

    Cysteine derivative found in Allium; NMDA NR2A/...

    ≥98%
  • D178589

    1-Deoxynojirimycin

    Anti-diabetic alkaloid

    ≥98%
  • A1096

    Acyclovir

    Nucleoside (guanosine) analog; DNA chain termin...

    ≥98%
  • D3348

    11,12-Dimethoxydihydrokawain

    Kawain derivative, lactone found in Piper methy...

    ≥97%
  • P7060

    Protocatechuic Acid Ethyl Ester

    Dihydroxyphenolic acid found in cruciferous veg...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only