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XL-147

XL-147

Product ID X4402
Cas No. 934526-89-3
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $58.50 In stock
5 mg $84.30 In stock
10 mg $162.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

XL-147 is an inhibitor of PI3K that is currently in clinical trials as a potential treatment for cancers with solid tumors. XL-147 exhibits anticancer chemotherapeutic properties, inhibiting tumor growth in animal models of acute lymphocytic leukemia (ALL). XL-147 is a dual inhibitor of PI3K and mTOR. It exhibits higher efficacy than either sole PI3K or mTOR inhibition in models of prostate cancer.

Product Info

Cas No.

934526-89-3

Purity

≥98%

Formula

C25H25ClN6O4S

Formula Wt.

541.02

IUPAC Name

N-[3-(2,1,3-benzothiadiazol-5-ylamino)quinoxalin-2-yl]-4-methylbenzenesulfonamide

Synonym

Pilaralisib, SAR245408

Solubility

DMSO 3 mg/mL (6.68 mM) Water Insoluble Ethanol Insoluble

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

X4402 MSDS PDF

Info Sheet

X4402 Info Sheet PDF

References

Shapiro GI, Rodon J, Bedell C, et al. Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245408 (XL147), an oral pan-class I PI3K inhibitor, in patients with advanced solid tumors. Clin Cancer Res. 2014 Jan 1;20(1):233-45. PMID: 24166903.

Reynolds CP, Kang MH, Carol H, et al. Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013 May;60(5):791-8. PMID: 23002019.

Gravina G., Mancini A., Dual PI3K/mTOR inhibitor, XL765 (SAR245409), shows superior effects to sole PI3K [XL147 (SAR245408)] or mTOR [rapamycin] inhibition in prostate cancer cell models. 37(1):341-51 (2016). PMID: 26219891.

Custom Order

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