Description
XL-147 is an inhibitor of PI3K that is currently in clinical trials as a potential treatment for cancers with solid tumors. XL-147 exhibits anticancer chemotherapeutic properties, inhibiting tumor growth in animal models of acute lymphocytic leukemia (ALL). XL-147 is a dual inhibitor of PI3K and mTOR. It exhibits higher efficacy than either sole PI3K or mTOR inhibition in models of prostate cancer.