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Z-VAD-FMK

Z-VAD-FMK

Product ID Z8401
Cas No. 187389-52-2
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $131.30 In stock
5 mg $498.80 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Z-VAD-FMK is a non-specific caspase inhibitor used to prevent caspase-mediated apoptosis in vitro. This peptide is primarily used in research models of apoptosis.

Product Info

Cas No.

187389-52-2

Purity

≥95%

Formula

C22H30FN3O7

Formula Wt.

467.49

Chemical Name

N-[(Benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxo-3-pentanyl]-L-alaninamide

IUPAC Name

N-[(Benzyloxy)carbonyl]-L-valyl-N-[(3S)-5-fluoro-1-methoxy-1,4-dioxo-3-pentanyl]-L-alaninamide

Synonym

Z-VAD(OMe)-FMK, pan-Caspase Inhibitor, Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Benzyloxycarbonyl-Val-Ala-DL-Asp(OMe)-fluoromethylketone, Caspase Inhibitor I

Solubility

Soluble in DMSO, acetonitrile, DMF.

Appearance

White solid.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

Z8401 MSDS PDF

Info Sheet

Z8401 Info Sheet PDF

References

Burmistrova O, Perdomo J, Simões MF, et al. The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells. Phytomedicine. 2015 Oct 15;22(11):1009-16. PMID: 26407943.

Choi EY, Shin KC, Lee J, et al. Treatment with a Small Synthetic Compound, KMU-193, induces Apoptosis in A549 Human Lung Carcinoma Cells through p53 Up-Regulation. Asian Pac J Cancer Prev. 2015;16(14):5883-7. PMID: 26320467.

Davis DA, Naiman NE, Wang V, et al. Identification of Caspase Cleavage Sites in KSHV Latency-Associated Nuclear Antigen and Their Effects on Caspase-Related Host Defense Responses. PLoS Pathog. 2015 Jul 28;11(7):e1005064. PMID: 26218605.

Custom Order

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  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
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