• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
Zerumbone

Zerumbone

Product ID Z1970
Cas No. 471-05-6
Purity ≥99%
Product Unit SizeCostQuantityStock
10 mg $67.80 In stock
50 mg $277.90 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Zerumbone is a cyclic sesquiterpene compound found in ginger root. Zerumbone exhibits a wide variety of beneficial properties, including anti-hyperlipidemic, anticancer chemotherapeutic, anti-angiogenic, antioxidative, antinociceptive, and anti-inflammatory activities. In an animal model of nonalcoholic fatty liver disease, zerumbone upregulates expression of PPARα and enzymes involved in lipid oxidation and downregulates expression of fatty acid synthase and lipogenic genes, resulting in decreased total cholesterol and triglyceride levels in plasma and improvements in lipid sensitivity. In several cancer cell lines, zerumbone inhibits expression of VEGF and activity of IKKα and NF-κB and activates caspases 3 and 9 and cleavage of poly(ADP)-ribose polymerase (PARP), resulting in apoptosis and decreased cellular proliferation. In both cellular and animal models, this compound displays antioxidative benefit, activating Nrf2 and increasing expression of heme oxygenase 1 (HO-1), resulting in decreased levels of reactive oxygen species (ROS). In vivo, zerumbone exhibits antinociceptive characteristics and is thought to act through L-arginine-NO-cGMP-PKC-K+ channel pathways and TRPV1 channels. Zerumbone also decreases paw edema and granulomatous tissue formation in animal models of inflammation.

Product Info

Cas No.

471-05-6

Purity

≥99%

Formula

C15H22O

Formula Wt.

218.33

Chemical Name

(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one

IUPAC Name

(2E,6E,10E)-2,6,9,9-tetramethylcycloundeca-2,6,10-trien-1-one

Solubility

DMSO (≥10 mg/mL)

Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C

Ship Temp

Ambient

Downloads

MSDS

Z1970 MSDS PDF

Info Sheet

Z1970 Info Sheet PDF

References

Tsuboi K, Matsuo Y, Shamoto T, et al. Zerumbone inhibits tumor angiogenesis via NF-κB in gastric cancer. Oncol Rep. 2014 Jan;31(1):57-64. PMID: 24220661.

Tzeng TF, Liou SS, Chang CJ, et al. Zerumbone, a Natural Cyclic Sesquiterpene of Zingiber zerumbet Smith, Attenuates Nonalcoholic Fatty Liver Disease in Hamsters Fed on High-Fat Diet. Evid Based Complement Alternat Med. 2013;2013:303061. PMID: 24223615.

Sun Y, Sheng Q, Cheng Y, et al. Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway. Pharmazie. 2013 Feb;68(2):141-5. PMID: 23469687.

Weng HY, Hsu MJ, Wang CC, et al. Zerumbone suppresses IKKα, Akt, and FOXO1 activation, resulting in apoptosis of GBM 8401 cells. J Biomed Sci. 2012 Oct 5;19:86. PMID: 23035900.

Shin JW, Ohnishi K, Murakami A, et al. Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2. Cancer Prev Res (Phila). 2011 Jun;4(6):860-70. PMID: 21367956.

Perimal EK, Akhtar MN, Mohamad AS, et al. Zerumbone-induced antinociception: involvement of the L-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways. Basic Clin Pharmacol Toxicol. 2011 Mar;108(3):155-62. PMID: 20955360.

Sulaiman MR, Perimal EK, Akhtar MN, et al. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia. 2010 Oct;81(7):855-8. PMID: 20546845.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • T1849

    Temozolomide

    Imidazotetrazine, DNA alkylator.

    ≥98%
  • E325127

    EIDD-1931

    Broad-spectrum antiviral activity against SARS-...

    ≥99%
  • V5734

    Vorinostat

    HDAC inhibitor, RNA splicing inhibitor.

    ≥98%
  • M2409

    MGCD-0103

    HDAC inhibitor.

    ≥98%
  • C822706

    Curvularin

    Macrocyclic lactone.

    ≥98%
  • T3036

    Thienylhexyl Isothiocyanate

    Thienylbutyl ITC analog.

    ≥97%
  • M3368

    Mirtazapine

    Piperazine; 5-HT1 agonist, 5-HT2/3 and α2-adre...

    ≥98%
  • P1755

    Pentoxifylline

    Xanthine derivative; adenosine A2 antagonist, P...

    ≥98%
  • C5654

    Concanavalin A

    Lectin found in Canavelia, plant mitogen that b...

  • C0367

    S-(−)-Carbidopa Monohydrate

    Hydrazine; L-amino acid decarboxylase inhibitor...

    ≥98%
  • G0246

    Galantamine Hydrobromide

    Alkaloid found in Galanthus, Narcissus, Leucoju...

    ≥98%
  • F1669

    Ferulic Acid

    Hydroxycinnamic acid found in various plant sou...

    ≥98%
  • N3208

    Nicardipine

    Dihydropyridine; L-type Ca2+ channel blocker.

    ≥99%
  • Z161024

    α-Zearalenol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • Z161025

    β-Zearalenol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • S020665

    Saquinavir

    Protease inhibitor

    ≥99%
  • P7318

    Pseudoginsenoside F11

    Saponin found in species of Panax; PPARγ agoni...

    ≥98%
  • C2900

    CH5424802

    ALK inhibitor.

    ≥99%
  • O1176

    n-Octyl Caffeate

    Caffeic acid derivative.

    ≥98%
  • G4596

    Glycidamide

    Epoxide metabolite of acrylamide, induces DNA a...

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only