LKT Labs

Biochemicals for Life Science Research

Lactacystin

Lactacystin

Product ID L0107
Cas No. 133343-34-7
Purity ≥98%
Product Unit SizeCostQuantityStock
100 µg $158.00 In stock
200 µg $278.00 In stock
500 µg $601.00 In stock
1 mg $1,127.00 Please Inquire
Bulk Quote

Quicklinks

Description

Lactacystin is a proteasome inhibitor initially produced by Streptomyces that exhibits hepatoprotective, anti-metastatic, and anticancer chemotherapeutic activities. Lactacystin increases the Bax/Bcl-2 ratio and inhibits proliferation of cells and growth of tumors in models of glioma. Additionally, lactacystin inhibits growth and migration of smooth muscle cells. In animal models of intestinal ischemia/reperfusion-induced liver injury, lactacystin inhibits activation of NF-κB, suppresses infiltration of neutrophils, and decreases levels of ICAM-1.

Product Info

Cas No.

133343-34-7
Purity

≥98%
Formula

C15H24N2O7S
Formula Wt.

376.43
IUPAC Name

(2R)-2-acetamido-3-[(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidine-2-carbonyl]sulfanylpropanoic acid
Solubility

Soluble DMSO or water.

Appearance

White Solid

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

L0107 MSDS PDF
Info Sheet

L0107 Info Sheet PDF

References

Wang H, Zhang S, Zhong J, et al. The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study. J Int Med Res. 2013 Feb;41(1):72-81. PMID: 23569132.

Barringhaus KG, Matsumura ME. The proteasome inhibitor lactacystin attenuates growth and migration of vascular smooth muscle cells and limits the response to arterial injury. Exp Clin Cardiol. 2007 Fall;12(3):119-24. PMID: 18650992.

Yao JH, Li YH, Wang ZZ, et al. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion. Clin Exp Pharmacol Physiol. 2007 Nov;34(11):1102-8. PMID: 17880361.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • D1760

    3-Acetyl-deoxynivalenol

    Type A trichothecene mycotoxin produced by Fusa...

    ≥98%
  • D022705

    Darunavir

    HIV and AIDS

    ≥99%
  • A4675

    Alternariol

    Mycotoxin produced by Alternaria; topoisomerase...

    ≥98%
  • A6264

    Apramycin Sulfate

    Aminoglycoside; protein translation inhibitor.<...

    ≥98%
  • R3206

    Riboflavin

    Essential vitamin (B2) found in vegetables, dai...

    ≥97%
  • C4457

    Clomipramine Hydrochloride

    FIASMA, mAChR, 5-HT2/3/6/7, α1/2-adrenergic an...

    ≥98%
  • O486181

    Omeprazole Related Compound B

    Impurity of omeprazole

    ≥99%
  • B8072

    3-tert-Butyl-5-Methoxycatechol

    BHA derivative, cellular differentiation induce...

    ≥95%
  • O610292

    Ophiobolin B

    Naturally occurring sesteterpenoid.

    ≥98%
  • S771337

    STING Agonist-1

    Indirect activator of STING signaling

    ≥98%
  • P691320

    PRI-724

    Wnt/beta-catenin/CBP inhibitor

    ≥98%
  • O9322

    Oxfendazole

    Benzimidazole; microtubule polymerization inhib...

    ≥98%
  • F7657

    Ftorafur

    5-fluorouracil prodrug, pyrimidine analog; thym...

    ≥99%
  • C0171

    Carboplatin

    Pt-based DNA cross-linker.

    ≥99%
  • M1444

    MDL 29951

    GPR17 agonist, NMDA and fructose 1,6-bisphospha...

    ≥98%
  • M1845

    Melitracen Hydrochloride

    Tricyclic antidepressant; potential D1/2 antago...

    ≥99%
  • G3355

    Ginkgolide B

    Terpene lactone found in Ginkgo; GlyR antagonis...

    ≥98%
  • F3206

    Fibrinolysis Inhibiting Factor

    Peptide; fibrinolysis inhibitor.

    ≥98%
  • G0175

    Gastric Inhibitory Peptide, human

    Endogenous peptide hormone, somatostatin analog...

    ≥95%
  • M4652

    MLN8237

    AurKA inhibitor.

    ≥98%