Description
Meleagrin is an indole alkaloid isolated from the fungus Penicillium chrysogenum. This FabI inhibiting antibiotic has also been found to have anti-tumor activities in various cell lines.
Meleagrin
Product ID M174446
Cas No. 71751-77-4
Purity ≥99%
| Product Unit Size | Cost | Quantity | Stock |
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Product Info
| Cas No. | 71751-77-4 |
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| Purity | ≥99% |
| Formula | C23H23N5O4 |
| Formula Wt. | 433.47 |
| Chemical Name | (3E,7aS,12aR)-6-Hydroxy-3-(1H-imidazol-4-ylmethylene)-12-methoxy-7a-(2-methyl-3-buten-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione |
| IUPAC Name | (3E,7aS,12aR)-6-Hydroxy-3-(1H-imidazol-4-ylmethylene)-12-methoxy-7a-(2-methyl-3-buten-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione |
| Synonym | Meleagrine;6-O-Methyloxaline, Meleagrine |
| Appearance | Light yellow powder |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
García-Estrada C1, Ullán RV, Albillos SM, et al. A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum. Chem Biol. 2011, 18(11):1499-512. doi: 10.1016/j.chembiol.2011.08.012. PMID: 22118684
Du L1, Feng T, Zhao B, et al. Alkaloids from a deep ocean sediment-derived fungus Penicillium sp. and their antitumor activities. J Antibiot (Tokyo). 2010 , 63(4):165-70. PMID: 20186171
Mady MS, Mohyeldin MM, Ebrahim HY, et al. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Bioorg Med Chem. 2016, 15;24(2):113-22. PMID: 26692349.