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Ricobendazole is an anti-parasitic nitroimidazole compound administered subcutaneously, unlike most nitroimidazoles. Ricobendazole binds the colchicine site of tubulin, inhibiting microtubule polymerization. Ricobendazole also exhibits anticancer activity, potentiating the effects of taxanes and inhibiting cell proliferation in breast cancer cells, non-small cell lung cancer (NSCLC) cells, and melanoma cells.
| Cas No. | 54029-12-8 |
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| Purity | ≥98% |
| Formula | C12H15N3O3S |
| Formula Wt. | 281.33 |
| Chemical Name | (5-propylsulfinyl)-1H-benzimidazol-2-yl)-methyl ester carbamic acid |
| IUPAC Name | methyl N-(6-propylsulfinyl-1H-benzimidazol-2-yl)carbamate |
| Synonym | (+-)-Albendazole sulfoxide, Albendazole oxide |
| Melting Point | 226-228°C (dec) |
| Appearance | White or yellowish white powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Lopes WD, Cruz BC, Soares VE, et al. Historic of therapeutic efficacy of albendazol sulphoxide administered in different routes, dosages and treatment schemes, against Taenia saginata cysticercus in cattle experimentally infected. Exp Parasitol. 2014 Feb;137:14-20. PMID: 24309372.
Belaz KR, Denadai M, Almeida AP, et al. Enantiomeric resolution of albendazole sulfoxide by semipreparative HPLC and in vitro study of growth inhibitory effects on human cancer cell lines. J Pharm Biomed Anal. 2012 Jul;66:100-8. PMID: 22487592.