Abamectin

Name: Abamectin
SKU: A0501
Availability: InStock

Product ID A0501

Cas No. 71751-41-2

Purity ≥70%

Product Unit Size	Cost	Quantity		Stock

Bulk Quote

Quicklinks

Description
Product Info
Shipping and Storage
Downloads
References

Description

Abamectin is a macrocyclic lactone avermectin, produced from the soil organism streptomyes avermitilis, that exhibits antibiotic and anti-fertility activities. Abamectin inhibits F0F1-ATPase and the adenine nucleotide translocator (ANT), preventing mitochondrial respiration and acting as an anti-parasitic/anti-helminthic. Additionally, abamectin decreases sperm count and motility and increases seminiferous tubule damage in male rats. This compound also inhibits GABA receptors in some models; other avermectins increase GABA release, indirectly stimulating activity of GABA receptors.

Product Info

Cas No.	71751-41-2
Purity	≥70%
Formula	C₄₈H₇₂O₁₄(B1a) C₄₇H₇₀O₁₄(B1b)
Chemical Name	Avermectin B(sub 1)
Synonym	Avermectin B1, 5-O-demethyl-25-de(91-methylpropyl)-25- (1-methylethyl)avermectin A1a (4:1)
Melting Point	150-155°C
Solubility	Soluble in methanol, acetone, isopropanol or toluene.
Appearance	White to off white powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	A0501 MSDS PDF
Info Sheet	A0501 Info Sheet PDF

References

Castanha Zanoli JC, Maioli MA, Medeiros HC, et al. Abamectin affects the bioenergetics of liver mitochondria: A potential mechanism of hepatotoxicity. Toxicol In Vitro. 2012 Feb;26(1):51-6. PMID: 22024101.

Celik-Ozenci C, Tasatargil A, Tekcan M, et al. Effects of abamectin exposure on male fertility in rats: potential role of oxidative stress-mediated poly(ADP-ribose) polymerase (PARP) activation. Regul Toxicol Pharmacol. 2011 Dec;61(3):310-7. PMID: 21945325.

Holden-Dye L, Walker RJ. Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? Parasitology. 1990 Oct;101 Pt 2:265-71. PMID: 2175874.

Custom Order

Name*
First Last
Company/Institution
Email*
Enter Email Confirm Email
Product ID
Product Name
Unit Size
Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
Unit Label
Quantity
Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
Comments
Name
This field is for validation purposes and should be left unchanged.

Abamectin

Quicklinks

Description

Product Info

Shipping and Storage

Downloads

References

Custom Order

Related Products

Biopterin

Zoledronic Acid Hydrate

Veratramine

P7C3A20

Clodronate Disodium Tetrahydrate

Amorolfine Hydrochloride

AZD-5438

Fluvastatin Sodium

Histrelin Acetate

17α-Hydroxyprogesterone Caproate

Maprotiline Hydrochloride

Triacetyl Aloe-emodin (Impurity A)

Aminophylline Anhydrous

β-Tocopherol

Albendazole

PD-325901

4-Thiouridine

Calcineurin Autoinhibitory Peptide

Cytochalasin C

Propafenone Hydrochloride

Footer