Abamectin

Name: Abamectin
SKU: A0501
Availability: InStock

Product ID A0501

Cas No. 71751-41-2

Purity ≥70%

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Description

Abamectin is a macrocyclic lactone avermectin, produced from the soil organism streptomyes avermitilis, that exhibits antibiotic and anti-fertility activities. Abamectin inhibits F0F1-ATPase and the adenine nucleotide translocator (ANT), preventing mitochondrial respiration and acting as an anti-parasitic/anti-helminthic. Additionally, abamectin decreases sperm count and motility and increases seminiferous tubule damage in male rats. This compound also inhibits GABA receptors in some models; other avermectins increase GABA release, indirectly stimulating activity of GABA receptors.

Product Info

Cas No.	71751-41-2
Purity	≥70%
Formula	C₄₈H₇₂O₁₄(B1a) C₄₇H₇₀O₁₄(B1b)
Chemical Name	Avermectin B(sub 1)
Synonym	Avermectin B1, 5-O-demethyl-25-de(91-methylpropyl)-25- (1-methylethyl)avermectin A1a (4:1)
Melting Point	150-155°C
Solubility	Soluble in methanol, acetone, isopropanol or toluene.
Appearance	White to off white powder

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	A0501 MSDS PDF
Info Sheet	A0501 Info Sheet PDF

References

Castanha Zanoli JC, Maioli MA, Medeiros HC, et al. Abamectin affects the bioenergetics of liver mitochondria: A potential mechanism of hepatotoxicity. Toxicol In Vitro. 2012 Feb;26(1):51-6. PMID: 22024101.

Celik-Ozenci C, Tasatargil A, Tekcan M, et al. Effects of abamectin exposure on male fertility in rats: potential role of oxidative stress-mediated poly(ADP-ribose) polymerase (PARP) activation. Regul Toxicol Pharmacol. 2011 Dec;61(3):310-7. PMID: 21945325.

Holden-Dye L, Walker RJ. Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? Parasitology. 1990 Oct;101 Pt 2:265-71. PMID: 2175874.

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Abamectin

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Description

Product Info

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Downloads

References

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