LKT Labs

Biochemicals for Life Science Research

Abamectin

Abamectin

Product ID A0501
Cas No. 71751-41-2
Purity ≥70%
Product Unit SizeCostQuantityStock
1 g $79.10 In stock
5 g $268.20 In stock
25 g $826.90 In stock
Bulk Quote

Quicklinks

Description

Abamectin is a macrocyclic lactone avermectin, produced from the soil organism streptomyes avermitilis, that exhibits antibiotic and anti-fertility activities. Abamectin inhibits F0F1-ATPase and the adenine nucleotide translocator (ANT), preventing mitochondrial respiration and acting as an anti-parasitic/anti-helminthic. Additionally, abamectin decreases sperm count and motility and increases seminiferous tubule damage in male rats. This compound also inhibits GABA receptors in some models; other avermectins increase GABA release, indirectly stimulating activity of GABA receptors.

Product Info

Cas No.

71751-41-2
Purity

≥70%
Formula

C48H72O14(B1a) C47H70O14(B1b)
Chemical Name

Avermectin B(sub 1)
Synonym

Avermectin B1, 5-O-demethyl-25-de(91-methylpropyl)-25- (1-methylethyl)avermectin A1a (4:1)
Melting Point

150-155°C
Solubility

Soluble in methanol, acetone, isopropanol or toluene.
Appearance

White to off white powder

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

A0501 MSDS PDF
Info Sheet

A0501 Info Sheet PDF

References

Castanha Zanoli JC, Maioli MA, Medeiros HC, et al. Abamectin affects the bioenergetics of liver mitochondria: A potential mechanism of hepatotoxicity. Toxicol In Vitro. 2012 Feb;26(1):51-6. PMID: 22024101.

Celik-Ozenci C, Tasatargil A, Tekcan M, et al. Effects of abamectin exposure on male fertility in rats: potential role of oxidative stress-mediated poly(ADP-ribose) polymerase (PARP) activation. Regul Toxicol Pharmacol. 2011 Dec;61(3):310-7. PMID: 21945325.

Holden-Dye L, Walker RJ. Avermectin and avermectin derivatives are antagonists at the 4-aminobutyric acid (GABA) receptor on the somatic muscle cells of Ascaris; is this the site of anthelmintic action? Parasitology. 1990 Oct;101 Pt 2:265-71. PMID: 2175874.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • B5560

    B-type Natriuretic Peptide (1-32), rat

    Endogenous cardiomodulatory peptide; NPR-A agon...

    ≥95%
  • G4781

    Glucoraphanin Potassium

    Glucosinolate found in cruciferous vegetables.<...

    ≥98%
  • O1200

    Odanacatib

    Cathepsin K inhibitor.

    ≥99%
  • T6902

    Tranilast

    Mast cell stabilizer; TRPV2 antagonist, PDGFR i...

    ≥98%
  • N0263

    Naphazoline Nitrate

    α1-adrenergic agonist.

    ≥97%
  • I7259

    Isoproterenol Hydrochloride

    β-adrenergic agonist.

    ≥98%
  • L0248

    Laminin Peptide YIGSR

    Laminin-derived peptapeptide.

    ≥98%
  • C4556

    Clofibric Acid

    Metabolite of clofibrate; PPARα agonist.

    ≥98%
  • C1868

    Cerebellin

    Peptide, involved in synapse formation and cell...

    ≥95%
  • T7032

    Triamcinolone

    Synthetic steroid; glucocorticoid agonist.

    ≥98%
  • A8644

    AVL-292

    BTK inhibitor.

    ≥98%
  • T0119

    Taxol Side Chain β-lactam

    Taxol synthesis intermediate.

    ≥98%
  • R8178

    Rutaecarpine

    Indoloquinazoline alkaloid found in Evodia; COX...

    ≥98%
  • G7345

    GSK-2606414

    PERK inhibitor.

    ≥99%
  • C0344

    Calphostin C

    Found in Cladosporium; PKC inhibitor.

    ≥95%
  • D1748

    Demeclocycline Hydrochloride

    Tetracycline; protein translation inhibitor, po...

    ≥85%
  • S0930

    Schisantherin A

    Dibenzocyclooctadiene found in Schisandra.

    ≥98%
  • K4401

    KL-1 Peptide

    Peptide, c-Kit ligand fragment.

    ≥95%
  • F5869

    N-formyl-Met-Ala-Ser

    Peptide, involved in neutrophil activation; FPR...

    ≥95%
  • A5478

    Antipain Dihydrochloride

    Oligopeptide found in Actinomycetes; protease i...