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SIS3 is a selective inhibitor of Smad3. Smad3 functions downstream of TGF-β and activin receptors, mediating their signaling. SIS3 suppresses Smad3 phosphorylation, thus inhibiting TGF-β and activin signaling independent of the MAPK, ERK, and PI3K pathways.
| Cas No. | 521984-48-5 |
|---|---|
| Purity | ≥98% |
| Formula | C28H28ClN3O3 |
| Formula Wt. | 490.00 |
| IUPAC Name | 1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride |
| Synonym | SIS3 HCl; CTK8E8838; KS-00000UAU |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Jinnin M., Ihn H., et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 69(2):597-607 (2006). PMID: 16288083.