Description
Ebselen is a synthetic glutathione peroxidase mimetic that reacts with cysteine residues; it exhibits antimicrobial, antibacterial, anti-diabetic, and antioxidative activities. Ebselen increases ROS and mitochondrial membrane potential, inhibiting GDH function in vitro. Additionally, ebselen inhibits yeast sporulation and binds the Mycobacterium Ag85 complex, preventing outer membrane synthesis. In diabetic rats, this compound prevents hyperglycemia, decreases glucose levels, Hb1Ac, and oxidative stress, and increases β-cell mass.