Description
TDZD-8 is an inhibitor of glycogen synthase kinase 3β (GSK-3β) that exhibits anti-inflammatory, anti-arthritic, and neuroprotective activities. TDZD-8 prevents hemorrhagic shock-induced changes in liver microcirculation and hepatocellular injury, inhibiting the inflammatory response and improving liver function in vivo. In rheumatoid arthritis synoviocytes, TDZD-8 decreases levels of p38 MAPK, ATF-2, c-jun, and JNK; in matched animal models, this compound decreases collagen-induced arthritis by inhibiting infiltration of T cells and macrophages as well as decreasing levels of IL-1β, IL-6, TNF-α, and IFN-γ. In other animal models, TDZD-8 improves deficits in spontaneous alternation in the Y-maze and changes in locomotor activity induced by amphetamines and viral-like immune activation.