LKT Labs

Biochemicals for Life Science Research

Citrinin

Citrinin

Product ID C3479
Cas No. 518-75-2
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $70.40 In stock
5 mg $236.50 In stock
10 mg $430.30 In stock
Bulk Quote

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Description

Citrinin is a mycotoxin initially produced by Penicillum, Aspergillus, and Monascus. Citrinin exhibits cytotoxic, cardiotoxic, nephrotoxic, and pro-oxidative activities. In leydig cells, citrinin inhibits testosterone production and induces caspase-mediated apoptosis. In embryos, citrinin alters heart morphology, causing malformations, edema, and red cell accumulation. Additionally, citrinin increases membrane permeability in mitochondria, increasing generation of ROS and superoxide anions.

Product Info

Cas No.

518-75-2
Purity

≥98%
Formula

C13H14O5
Formula Wt.

250.249
IUPAC Name

(3R,4S)-6-hydroxy-3,4,5-trimethyl-8-oxo-3, 4-dihydroisochromene-7-carboxylic acid
Melting Point

175°C (dec.)
Appearance

Yellow Crystals

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

C3479 MSDS PDF
Info Sheet

C3479 Info Sheet PDF

References

Wu TS, Yang JJ, Yu FY, et al. Cardiotoxicity of mycotoxin citrinin and involvement of microRNA-138 in zebrafish embryos. Toxicol Sci. 2013 Dec;136(2):402-12. PMID: 24052562.

Liu S, Wang D, Zhang J, et al. Citrinin reduces testosterone secretion by inducing apoptosis in rat Leydig cells. Toxicol In Vitro. 2012 Sep;26(6):856-61. PMID: 22564900.

Flajs D, Peraica M. Toxicological properties of citrinin. Arh Hig Rada Toksikol. 2009 Dec;60(4):457-64. PMID: 20061247.

Da Lozzo EJ, Oliveira MB, Carnieri EG. Citrinin-induced mitochondrial permeability transition. J Biochem Mol Toxicol. 1998;12(5):291-7. PMID: 9664235.

Ribeiro SM, Chagas GM, Campello AP, et al. Mechanism of citrinin-induced dysfunction of mitochondria. V. Effect on the homeostasis of the reactive oxygen species. Cell Biochem Funct. 1997 Sep;15(3):203-9. PMID: 9377799.

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