Cefazolin

Name: Cefazolin
SKU: C167200
Availability: InStock

Product ID C167200

Cas No. 25953-19-9

Purity ≥98%

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Description

Cefazolin is a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
NCI Thesaurus (NCIt)
https://ncithesaurus.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C2891

Product Info

Cas No.	25953-19-9
Purity	≥98%
Formula	C₁₄H₁₄N₈O₄S₃
Formula Wt.	454.50
Chemical Name	(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
IUPAC Name	(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Synonym	Cephazolin, Cefazolin acid; Cephamezine
Melting Point	197-200°C (dec)

Shipping and Storage

Store Temp	4°C
Ship Temp	Ambient

Downloads

MSDS	C167200 MSDS PDF
Info Sheet	C167200 Info Sheet PDF

References

Pagan-Rivera L, Godoy-Vitorino F, Melendez-Vazquez N, et al. The effect of cefazolin on the gut microbiome of female rats after spinal ocrd injury. Microorganisms. 2025 Oct 7;13(10):2324. PMID: 41156784.

Onita T, Ikawa K, Ishihara N, et al. Cerebrospinal pharmacokinetic modeling and pharmacodynamic simulation of high-dose cefazolin for meningitis caused by methicillin-susceptible Staphylococcus aureus. Antibiotics (Basel). 2025 Oct 11;14(10):1008. PMID: 41148700.

Mellett M, Riel J, Corsini R, et al. The combinations of cefazolin with linezolid and cefazolin with clindamycin are indifferent against methicillin-susceptible Staphylococcus aureus. Microbiol Spectr. 2025 Sep 30:e0176325. PMID: 41025660.

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Cefazolin

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