Description
AB-680 is an inhibitor of CD73, which plays a key role in tumor growth, metastasis, and tumor-associated macrophage upregulation.
Product Unit Size | Cost | Quantity | Stock |
---|
AB-680 is an inhibitor of CD73, which plays a key role in tumor growth, metastasis, and tumor-associated macrophage upregulation.
Cas No. | 2105904-82-1 |
---|---|
Purity | ≥98% |
Formula | C20H24ClFN4O9P2 |
Formula Wt. | 580.83 |
IUPAC Name | [[(2R,3S,4R,5R)-5-[6-chloro-4-[[(1S)-1-(2-fluorophenyl)ethyl]amino]pyrazolo[3,4-b]pyridin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]methylphosphonic acid |
Synonym | AB680, Quemliclustat |
Appearance | Off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
Info Sheet |
---|
Faraoni E, Strickland L, O’Brien B, et al. Radiofrequency ablation in combination with CD73 inhibitor AB680 reduces tumor growth and enhances anti-tumor immunity in a syngeneic model of pancreatic ductal adenocarcinoma. Front Oncol. 2022 Sep 6;12:995027. PMID: 36147911
Noh J, Lee I, Han N, et al. Additive effect of CD73 inhibitor in colorectal cancer treatment with CDK4/6 inhibitor through regulation of PD-L1. Cell Mol Gastroenterol Hepatol. 2022;14(4):769-788. PMID: 35843546
Kim M, Min Y, Jang J, et al. Single-cell RNA sequencing reveals distinct cellular factors for response to immunotherapy targeting CD73 and PD-1 in colorectal cancer. J Immunother Cancer. 2021 Jul;9(7):e002503. PMID: 34253638
Selective positive allosteric modulator of AMPA...
Endogenous peptide hormone, involved in stress ...
Found in Colchicum; microtubule polymerization ...
Triazole; 14-α demethylase inhibitor, voltage-...
Mixture of oligomycins A, B, C; oxidative phosp...
Iron chelator.
Alternaria mycotoxin which may be found in food...
Downregulates LPS-stimulated expression of pro-...
MGMT inhibitor.
InsR and IGF-1R inhibitor.
Insect sterilizer; mutagenic.
β2-adrenergic agonist.
PI3K and PDK1 inhibitor.
TrkB agonist.
Cyclohexanecarboxylic acid found in various pla...
Sulfonylurea; ATP-sensitive K+ channel blocker....
Diterpene originally found in Rabdosia.
Anthraquinone found in aloe; CTFR Cl- channel a...
CDK4/6 inhibitor.
Dihydropyridine; L-type Ca2+ channel blocker.