LKT Labs

Biochemicals for Life Science Research

Spinorphin, bovine

Spinorphin, bovine

Product ID S6134
Cas No. 137201-62-8
Purity ≥95%
Product Unit SizeCostQuantityStock
5 mg $233.00 Please Inquire
10 mg $388.00 In stock
25 mg $777.00 Please Inquire
Bulk Quote

Quicklinks

Description

Spinorphin is a heptapeptide with the sequence L-V-V-Y-P-W-T. Spinorphin is an endogenous enkephalinase inhibitor, antagonizing enzymes such as aminopeptidase IV, neutral endopeptidase, dipeptidyl peptidase III (DPP3), and angiotensin-converting enzyme (ACE); it also acts as an antagonist at the P2X3 receptor. Spinorphin exhibits antinociceptive, antidepressant, gastrointestinal motility modulating, anti-inflammatory, and immunomodulatory activities. Spinorphin also acts as an antagonist at N-formylpeptide receptors, preventing binding of chemotactic f-MLF to its receptor on polymorphonuclear (PMN) neutrophils and inhibiting neutrophil functionality.

Product Info

Cas No.

137201-62-8
Purity

≥95%
Formula

C45H64N8O10
Formula Wt.

877.06
IUPAC Name

(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoic acid
Solubility

Soluble in water (1 mg/mL).
Appearance

White to off white powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

S6134 MSDS PDF
Info Sheet

S6134 Info Sheet PDF

References

Thanawala V, Kadam VJ, Ghosh R. Enkephalinase inhibitors: potential agents for the management of pain. Curr Drug Targets. 2008 Oct;9(10):887-94. PMID: 18855623.

Jung KY, Moon HD, Lee GE, et al. Structure-activity relationship studies of spinorphin as a potent and selective human P2X(3) receptor antagonist. J Med Chem. 2007 Sep 6;50(18):4543-7. PMID: 17676725.

Yamamoto Y, Ono H, Ueda A, et al. Spinorphin as an endogenous inhibitor of enkephalin-degrading enzymes: roles in pain and inflammation. Curr Protein Pept Sci. 2002 Dec;3(6):587-99. PMID: 12470213.

Liang TS, Gao JL, Fatemi O, et al. The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR. J Immunol. 2001 Dec 1;167(11):6609-14. PMID: 11714831.

Nishimura K, Hazato T. Isolation and identification of an endogenous inhibitor of enkephalin-degrading enzymes from bovine spinal cord. Biochem Biophys Res Commun. 1993 Jul 30;194(2):713-9. PMID: 8343155.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E7731

    17-α-Ethynylestradiol

    Synthetic steroid hormone; ER agonist.

    ≥99%
  • Z161023

    β-Zearalanol

    Mycotoxin that has structural similarity to est...

    ≥98%
  • O610292

    Ophiobolin B

    Naturally occurring sesteterpenoid.

    ≥98%
  • P465822

    Pluripotin

    Dual kinase and GTPase inhibitor.

    ≥98%
  • F5968

    Foretinib

    ROS1, MET, Ron, Axl, TIE-2, VEGFR2 inhibitor.

    ≥98%
  • O0400

    Obatoclax

    BH3 mimetic; Bcl-2 and Bcl-xl inhibitor.

    ≥98%
  • S822687

    Surfactin

    Amphiphilic properties

    ≥90% mixed isomers
  • S8009

    Substance P (7-11)

    Endogenous tachykinin peptide, involved in infl...

    ≥95%
  • L0400

    LB-100

    PP2A inhibitor.

    ≥98%
  • T0298

    Tazobactam

    β-lactamase inhibitor.

    ≥98%
  • A744789

    ASTX660

    Antitumor

    ≥98%
  • S5749

    Somatostatin-14

    Endogenous neuropeptide hormone; somatostatin a...

    ≥95%
  • T7035

    Triptolide

    Diterpenoid epoxide found in Tripterygium.

    ≥98%
  • E7578

    Estramustine

    Nitrogen mustard and estradiol derivative; micr...

    ≥97%
  • M1644

    Meloxicam

    NSAID; COX-2 inhibitor.

    ≥98%
  • M1879

    Metoprolol Tartrate

    β1-adrenergic antagonist.

    ≥98%
  • I7341

    Isoniazid

    Nicotinic acid derivative; InhA inhibitor.

    ≥98%
  • G7442

    GSK-343

    EZH2 HMT inhibitor.

    ≥98%
  • A4498

    Alytesin

    Antimicrobial peptide found in amphibians.

    ≥95%
  • P8270

    Purvalanol A

    Purine derivative; CDK inhibitor.

    ≥98%