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Dapiprazole is an α1-adrenergic antagonist that displays preference for α1A and α1D receptors over α1B receptors. Dapiprazole is used as a miotic compound, evoking pupillary constriction and reversing mydriasis or dilation. Additionally, dapiprazole decreases mean intraocular pressure in patients with glaucoma. Dapiprazole also decreases pigment shedding and increases outflow facility and pigment clearance in patients with pigmentary glaucoma.
| Cas No. | 72822-13-0 |
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| Purity | ≥98% |
| Formula | C19H27N5 • HCl |
| Formula Wt. | 361.91 |
| Chemical Name | 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridine;hydrochloride |
| IUPAC Name | 3-[2-[4-(2-methylphenyl)piperazin-1-yl]ethyl]-5,6,7,8-tetrahydro-[1,2, 4]triazolo[4,3-a]pyridine;hydrochloride |
| Synonym | Rev-Eyes |
| Appearance | White Crystal Powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Eltze M. Affinity of the miotic drug, dapiprazole, at alpha 1-adrenoceptor subtypes A, B and D. J Pharm Pharmacol. 1997 Nov;49(11):1091-5. PMID: 9401944.
Hogan TS, McDaniel DD, Bartlett JD, et al. Dose-response study of dapiprazole HCl in the reversal of mydriasis induced by 2.5% phenylephrine. J Ocul Pharmacol Ther. 1997 Aug;13(4):297-302. PMID: 9261765.
Mastropasqua L, Carpineto P, Ciancaglini M, et al. The usefulness of dapiprazole, an alpha-adrenergic blocking agent, in pigmentary glaucoma. Ophthalmic Surg Lasers. 1996 Sep;27(9):806-9. PMID: 8878205.
Mastropasqua L, Carpineto P, Ciancaglini M, et al. Effect of dapiprazole, an alpha-adrenergic blocking agent, on aqueous humor dynamics in pigmentary glaucoma. Ophthalmic Res. 1996;28(5):312-8. PMID: 8979280.
Nyman N, Reich L. The effect of dapiprazole on accommodative amplitude in eyes dilated with 0.5 percent tropicamide. J Am Optom Assoc. 1993 Sep;64(9):625-8. PMID: 7901257.