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Inosine is a purine nucleoside derivative of adenosine. Inosine binds directly to the A2A receptor and activates adenylyl cyclase promoting neuroprotective effect. Inosine also may inhibit the activity of ubiquitin-activating enzyme 6 to increase the immunogenicity of tumor cells.
| Cas No. | 58-63-9 |
|---|---|
| Purity | ≥98% |
| Formula | C10H12N4O5 |
| Formula Wt. | 268.23 |
| Chemical Name | 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one |
| IUPAC Name | 9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one |
| Synonym | Hypoxanthosine; Ribonosine; Atorel; Oxiamin; Hypoxanthine riboside; Trophicardyl; Selfer; Pantholic-L |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| Info Sheet |
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Cardoso F, Maria G, Pestana F, et al. Nerve repair with polylactic acid and inosine treatment enhance regeneration and improve functional recovery after sciatic nerve transection. Fron Cell Neurosci. 2025 Jan 6:18:1525024. PMID: 39835292.
Ma Y, Qian X, Yu Q, et al. Inosine prevents colorectal cancer progression by inducing M1 phenotypic polarization of macrophages. Molecules. 2024 Dec 31;30(1):123. PMID: 39795180.
Khanal S, Shin E, Yoo C, et al. Inosine exerts dopaminergic neuroprotective effects via mitigation of NLRP3 inflammasome activation. Neuropharmacology. 2025 Mar 15:266:110278. PMID: 39725121.