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Arenobufagin is a bufanolide steroid found in the Argentine toad Bufo arenarum. This compound exhibits anticancer chemotherapeutic and anti-angiogenic properties, but is also cardiotoxic, inhibiting cardiovascular Na+/K+ pumps. In cellular models, arenobufagin induces autophagy and apoptosis, inhibiting tumor growth through indirect inhibition of the PI3K/Akt/mTOR signaling pathway. Arenobufagin also inhibits VEGFR2 directly through blockade of ATP-binding sites.
| Cas No. | 464-74-4 |
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| Purity | ≥98% |
| Formula | C24H32O6 |
| Formula Wt. | 416.51 |
| IUPAC Name | 5-[(3S,5R,8R,9S,10S,11S,13R,14S,17R)-3,11,14-trihydroxy-10, 13-dimethyl-12-oxo-2,3,4,5,6,7,8,9,11,15,16, 17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]pyran-2-one |
| Solubility | 10mM in DMSO |
| Appearance | White Crystal Powder |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhang DM, Liu JS, Deng LJ, et al. Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway. Carcinogenesis. 2013 Jun;34(6):1331-42. PMID: 23393227.
Li M, Wu S, Liu Z, et al. Arenobufagin, a bufadienolide compound from toad venom, inhibits VEGF-mediated angiogenesis through suppression of VEGFR-2 signaling pathway. Biochem Pharmacol. 2012 May 1;83(9):1251-60. PMID: 22305746.
Cruz Jdos S, Matsuda H. Arenobufagin, a compound in toad venom, blocks Na(+)-K+ pump current in cardiac myocytes. Eur J Pharmacol. 1993 Aug 3;239(1-3):223-6. PMID: 8223897.
Garraffo HM, Gros EG. Biosynthesis of bufadienolides in toads. VI. Experiments with [1,2-3H]cholesterol, [21-14C]coprostanol, and 5 beta-[21-14 C]pregnanolone in the toad Bufo arenarum. Steroids. 1986 Sep-Oct;48(3-4):251-7. PMID: 3127947.