Description
AMG-208 is an inhibitor of c-MET and Ron that exhibits anticancer chemotherapeutic activity in prostate cancer models in vitro and in vivo.
Product Unit Size | Cost | Quantity | Stock |
---|
AMG-208 is an inhibitor of c-MET and Ron that exhibits anticancer chemotherapeutic activity in prostate cancer models in vitro and in vivo.
Cas No. | 1002304-34-8 |
---|---|
Purity | ≥98% |
Formula | C22H17N5O2 |
Formula Wt. | 383.40 |
Chemical Name | 7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline |
IUPAC Name | 7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline |
Synonym | AMG208; AMG 208 |
Solubility | DMSO 0.25 mg/mL (0.65 mM) Water Insoluble Ethanol Insoluble |
Appearance | White to off white powder |
Store Temp | -20°C |
---|---|
Ship Temp | Ambient |
MSDS | |
---|---|
Info Sheet |
Liu X, Newton RC, Scherle PA. Developing c-MET pathway inhibitors for cancer therapy: progress and challenges. Trends Mol Med. 2010 Jan;16(1):37-45. PMID: 20031486.
Albrecht BK, Harmange JC, Bauer D, et al. Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase. J Med Chem. 2008 May 22;51(10):2879-82. PMID: 18426196.
Protease inhibitor.
BRD2/4/9 and CECR2 inhibitor.
Fermentation impurity
Diterpene found in brewed, unfiltered coffee; F...
Endogenous peptide, cleavage product of angiote...
BRD binding agent, CDK1/2/5/9 inhibitor.
Sulfonamide; PABA inhibitor.
Endogenous quaternary ammonium, required for fa...
Antibiotic
β1/2-adrenergic antagonist.
Inhibitor of CDK.
Abl, PDGFR, EphR, Src, k-Kit, FYN, LCK, HCK inh...
Proteasome inhibitor, miR33b modulator.
Endogenous peptide hormone fragment, involved i...
Side chain commonly attached to taxanes.
NSAID; COX-2 inhibitor.
Non-steroid; AR antagonist.
Glycolic acid ester prodrug of indomethacin, NS...
KRAS inhibitor
Protease substrate.