LKT Labs

Biochemicals for Life Science Research

VE-821

VE-821

Product ID V1600
Cas No. 1232410-49-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $53.00 In stock
5 mg $89.00 In stock
10 mg $142.00 In stock
Bulk Quote

Quicklinks

Description

VE-821 is an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase, a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest. VE-821 exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro. VE-821 decreases phosphorylation of checkpoint kinase (CHK) 1 and induces G2 phase cell cycle arrest in pancreatic cancer cells and leukemia cells, sensitizing them to the effects of radiation.

Product Info

Cas No.

1232410-49-9
Purity

≥98%
Formula

C18H16N4O3S
Formula Wt.

368.41
IUPAC Name

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
Synonym

VE821
Solubility

DMSO 74 mg/mL (200.86 mM) Water Insoluble Ethanol Insoluble
Appearance

Light yellow powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

V1600 MSDS PDF
Info Sheet

V1600 Info Sheet PDF

References

Flynn RL, Cox KE, Jeitany M, et al. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16;347(6219):273-7. PMID: 25593184.

Vávrová J, Zárybnická L, Lukášová E, et al. Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60). Radiat Environ Biophys. 2013 Nov;52(4):471-9. PMID: 23934411.

Prevo R, Fokas E, Reaper PM, et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther. 2012 Sep;13(11):1072-81. PMID: 22825331.

Reaper PM, Griffiths MR, Long JM, et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011 Apr 13;7(7):428-30. PMID: 21490603.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • A0248

    BAM-12P

    Peptide, cleavage product of proenkephalin; κO...

    ≥95%
  • A001001

    A 83-01

    TGFbeta receptor inhibitor

    ≥98%
  • E6993

    Erythromycin Resistance Peptide MRLFV

    Peptide, confers resistance against macrolide a...

    ≥95%
  • B6809

    [DPhe7]-Bradykinin

    Natriuretic, vasodilatory peptide, bradykinin a...

    ≥95%
  • T291321

    Thiamine Mononitrate

    Vitamin B1

    ≥98%
  • K0088

    Kawain

    Kavalactone originally found in Piper methystic...

    ≥98%
  • L1878

    Letrozole

    Aromatase inhibitor.

    ≥98%
  • D0363

    Daptomycin

    Anionic lipopeptide, alters cell membrane organ...

    ≥97%
  • T6834

    Triacsin C

    Acyl-CoA synthetase inhibitor.

    ≥95%
  • N3476

    Nitisinone

    Nitrobenzene; HPPD inhibitor.

    ≥99%
  • P6859

    Proctolin

    Neuropeptide found in crustaceans and insects.<...

    ≥95%
  • G3556

    Ginsenoside Rg3

    Triterpene saponin found in species of Panax; Î...

    ≥98%
  • V9200

    VX-950

    NS3/4A serine protease inhibitor.

    ≥98%
  • D5869

    Doripenem Hydrate

    β-lactam carbapenem; penicillin binding protei...

    ≥99%
  • M400220

    MK-2206 Dihydrochloride

    Akt inhibitor.

    ≥99%
  • J6400

    (+)-JQ-1

    Triazolothienodiazepine; BRD inhibitor.

    ≥99%
  • P8168

    Puromycin Dihydrochloride

    Protein synthesis inhibitor, DPP2 and metallope...

    ≥98%
  • C3578

    L-Citrulline

    Byproduct of L-arginine metabolism found in wat...

    ≥98%
  • T982698

    L-Tyrosine disodium salt

    Amino acid precursor of dopamine.

    ≥98%
  • R2713

    Recombinant HCV-NS4 Antigens

    Recombinant HCV antigen fragment.

    ≥95%