LKT Labs

Biochemicals for Life Science Research

VE-821

VE-821

Product ID V1600
Cas No. 1232410-49-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $53.00 In stock
5 mg $89.00 In stock
10 mg $142.00 In stock
Bulk Quote

Quicklinks

Description

VE-821 is an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase, a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest. VE-821 exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro. VE-821 decreases phosphorylation of checkpoint kinase (CHK) 1 and induces G2 phase cell cycle arrest in pancreatic cancer cells and leukemia cells, sensitizing them to the effects of radiation.

Product Info

Cas No.

1232410-49-9
Purity

≥98%
Formula

C18H16N4O3S
Formula Wt.

368.41
IUPAC Name

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
Synonym

VE821
Solubility

DMSO 74 mg/mL (200.86 mM) Water Insoluble Ethanol Insoluble
Appearance

Light yellow powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

V1600 MSDS PDF
Info Sheet

V1600 Info Sheet PDF

References

Flynn RL, Cox KE, Jeitany M, et al. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16;347(6219):273-7. PMID: 25593184.

Vávrová J, Zárybnická L, Lukášová E, et al. Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60). Radiat Environ Biophys. 2013 Nov;52(4):471-9. PMID: 23934411.

Prevo R, Fokas E, Reaper PM, et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther. 2012 Sep;13(11):1072-81. PMID: 22825331.

Reaper PM, Griffiths MR, Long JM, et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011 Apr 13;7(7):428-30. PMID: 21490603.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • N1982

    Neuromedin U, rat

    Endogenous neuropeptide, involved in energy hom...

    ≥95%
  • I525138

    Indoximod

    Indoleamine 2,3-dioxygenase inhibitor.

    ≥98%
  • S0225

    SAG Dihydrochloride

    Smoothened agonist.

    ≥98%
  • C458567

    Clofazimine

    Antibacterial (Antimyobacterial) agent.

    ≥99%
  • D3208

    Diclazuril

    Coccidiostat, GAPDH inhibitor.

    ≥98%
  • A1016

    S-Acetyl-L-glutathione

    Alters intracellular glutathione levels.

    ≥98%
  • U6901

    Uracil

    Endogenous pyrimidine base required for product...

    ≥98%
  • G4634

    Glipizide

    Sulfonylurea; ATP-sensitive K+ channel blocker....

    ≥98%
  • A4438

    Allatostatin I

    Neuropeptide found in insects; juvenile hormone...

    ≥95%
  • C0396

    CAY10505

    p110γ PI3K inhibitor.

    ≥98%
  • P6801

    Pravastatin Sodium

    Statin; HMG-CoA reductase inhibitor.

    ≥98%
  • R1777

    9-cis-Retinoic Acid

    Vitamin A derivative; RAR and RXR agonist.

    ≥99%
  • P6957

    Protopanaxadiol

    Triterpene sapogenin found in species of Panax;...

    ≥98%
  • N0114

    Nadifloxacin

    Fluoroquinolone; bacterial DNA gyrase inhibitor...

    ≥98%
  • S5749

    Somatostatin-14

    Endogenous neuropeptide hormone; somatostatin a...

    ≥95%
  • A040068

    AB-680

    CD73 inhibitor

    ≥98%
  • I0418

    Iberverin

    ITC found in cruciferous vegetables, homolog of...

    ≥98%
  • A3208

    AICAR

    AMPK activator.

    ≥98%
  • G4596

    Glycidamide

    Epoxide metabolite of acrylamide, induces DNA a...

    ≥98%
  • G1651

    Geniposidic Acid

    Iridoid glucoside found in Eucommia, Castilleja...

    ≥98%