LKT Labs

Biochemicals for Life Science Research

VE-821

VE-821

Product ID V1600
Cas No. 1232410-49-9
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $52.50 In stock
5 mg $89.30 In stock
10 mg $141.80 In stock
Bulk Quote

Quicklinks

Description

VE-821 is an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase, a chromatin-remodeling protein that senses DNA damage and activates the DNA damage checkpoint to induce cell cycle arrest. VE-821 exhibits anticancer activity, inducing chromosome fragmentation, apoptosis, and cell death in vitro. VE-821 decreases phosphorylation of checkpoint kinase (CHK) 1 and induces G2 phase cell cycle arrest in pancreatic cancer cells and leukemia cells, sensitizing them to the effects of radiation.

Product Info

Cas No.

1232410-49-9
Purity

≥98%
Formula

C18H16N4O3S
Formula Wt.

368.41
IUPAC Name

3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
Synonym

VE821
Solubility

DMSO 74 mg/mL (200.86 mM) Water Insoluble Ethanol Insoluble
Appearance

Light yellow powder

Shipping and Storage

Store Temp

-20°C
Ship Temp

Ambient

Downloads

MSDS

V1600 MSDS PDF
Info Sheet

V1600 Info Sheet PDF

References

Flynn RL, Cox KE, Jeitany M, et al. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 2015 Jan 16;347(6219):273-7. PMID: 25593184.

Vávrová J, Zárybnická L, Lukášová E, et al. Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60). Radiat Environ Biophys. 2013 Nov;52(4):471-9. PMID: 23934411.

Prevo R, Fokas E, Reaper PM, et al. The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy. Cancer Biol Ther. 2012 Sep;13(11):1072-81. PMID: 22825331.

Reaper PM, Griffiths MR, Long JM, et al. Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR. Nat Chem Biol. 2011 Apr 13;7(7):428-30. PMID: 21490603.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • P2922

    Phenylhexyl Isothiocyanate

    ITC found in cruciferous vegetables; HDAC inhib...

    ≥98%
  • I2118

    Ifenprodil Hemitartrate

    NMDA NR1/NR2B antagonist.

    ≥98%
  • L1044

    LCL-161

    SMAC mimetic; PXR agonist, IAP inhibitor.

    ≥99%, ≥99%ee, de
  • R3347

    Riluzole

    Benzothiazole; TRPC5 agonist, PTR1 inhibitor, v...

    ≥98%
  • D8276

    Dutasteride

    5-α-Reductase inhibitor.

    ≥99%
  • H0003

    H89

    PKA inhibitor, potential ROCK, S6K1, MSK1, PKB ...

    ≥98%
  • P298576

    Phomopsin A

    Cyclic hexapeptide isolated from Phomopsis lept...

    ≥98%
  • F4781

    Fludarabine

    Nucleoside (adenosine) analog; DNA chain termin...

    ≥98%
  • A1319

    Adenosine Triphosphate Disodium Hydrate

    Endogenous coenzyme, unit of cellular energy, r...

    ≥95%
  • D0363

    Daptomycin

    Anionic lipopeptide, alters cell membrane organ...

    ≥97%
  • A4924

    AMG-208

    c-MET and Ron inhibitor.

    ≥98%
  • T0142

    TAK-733

    MEK inhibitor.

    ≥98%
  • P2815

    Phenylbutyrate Sodium

    HDAC inhibitor.

    ≥98%
  • P6818

    Prednisolone

    Cortisol derivative; glucocorticoid agonist.

    ≥98%
  • C3246

    Cilostazol

    Quinoline; PDE 3B inhibitor.

    ≥98%
  • M174446

    Meleagrin

    FabI inhibitor

    ≥99%
  • K0023

    K252c

    Staurosporine analog; PKC and PKA inhibitor.

    ≥98%
  • C8070

    Curcumin, high purity

    Active compound found in turmeric; MST1 activat...

    ≥98%
  • S8345

    S-(−)-Sulpiride

    GHB agonist, D2/3 antagonist.

    ≥99%
  • M0126

    Magainin 2

    Antimicrobial peptide found in frogs, induces p...

    ≥95%