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PluriSin 1 is a pluripotent cell-specific inhibitor that induces endoplasmic reticular stress and apoptosis in pluripotent stem cells. This compound inhibits stearoyl-coA desaturase 1 (SCD1), preventing teratoma formation in tumorigenic undifferentiated cells. Plurisin1 prevents undifferentiated cells from developing into tumors when used to regenerate tissues such as the heart.
| Cas No. | 91396-88-2 |
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| Purity | ≥98% |
| Formula | C12H11N3O |
| Formula Wt. | 213.24 |
| IUPAC Name | N'-Phenylisonicotinohydrazide |
| Synonym | NSC 14613, PluriSln 1, Isonicotinic Acid 2-Phenylhydrazide, Plurisin #1 |
| Solubility | 10mM in DMSO |
| Store Temp | -20°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Zhang L, Pan Y, Qin G, et al. Inhibition of stearoyl-coA desaturase selectively eliminates tumorigenic Nanog-positive cells: improving the safety of iPS cell transplantation to myocardium. Cell Cycle. 2014;13(5):762-71. PMID: 24394703.
Ben-David U, Gan QF, Golan-Lev T, et al. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell. 2013 Feb 7;12(2):167-79. PMID: 23318055.