GW-788388

Name: GW-788388
SKU: G8800
Availability: InStock

Product ID G8800

Cas No. 452342-67-5

Purity ≥97%

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Description

GW-788388 inhibits activin receptor-like kinase 5 (ALK5), suppressing TGF-β activity; it exhibits anti-fibrotic and cardioprotective activities. GW-788388 increases survival in studies of Trypanosoma infection and prevents Chagas disease-induced development of cardiac fibrosis. This compound also attenuates systolic dysfunction and left ventricular remodeling in animal models of myocardial infarction. In animal models of diabetes, GW-788388 decreases the occurrence of renal fibrosis.

Product Info

Cas No.	452342-67-5
Purity	≥97%
Formula	C₂₅H₂₃N₅O₂
Formula Wt.	425.49
IUPAC Name	4-{4-[5-(2-Pyridinyl)-1H-pyrazol-4-yl]-2-pyridinyl}-N-(tetrahydro-2H-pyran-4-yl)benzamide
Synonym	GW788388, GW 788388
Solubility	DMSO Solubility: 15 mg/mL (35.25 mM)

Shipping and Storage

Store Temp	-20°C
Ship Temp	Ambient

Downloads

MSDS	G8800 MSDS PDF
Info Sheet	G8800 Info Sheet PDF

References

de Oliveira FL, Araújo-Jorge TC, de Souza EM, et al. Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. PLoS Negl Trop Dis. 2012;6(6):e1696. PMID: 22720109.

Tan SM, Zhang Y, Connelly KA, et al. Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. Am J Physiol Heart Circ Physiol. 2010 May;298(5):H1415-25. PMID: 20154262.

Petersen M, Thorikay M, Deckers M, et al. Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney Int. 2008 Mar;73(6):705-15. PMID: 18075500.

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GW-788388

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