Description
KX1-004 is an indole that inhibits Src. This compound decreases apoptosis in hair cells to prevent noise-induced hearing loss.
KX1-004
Product ID K9200
Cas No. 518058-84-9
Purity ≥98%
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Product Info
| Cas No. | 518058-84-9 |
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| Purity | ≥98% |
| Formula | C16H13FN2O2 |
| Formula Wt. | 284.29 |
| Chemical Name | 5-Fluoro-N-(3-hydroxybenzyl)-1H-indole-2-carboxamide |
| IUPAC Name | 5-Fluoro-N-(3-hydroxybenzyl)-1H-indole-2-carboxamide |
| Synonym | KX1004, C16H13FN2O2 |
| Solubility | DMSO: ≥ 42 mg/mL |
Shipping and Storage
| Store Temp | -20°C |
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| Ship Temp | Ambient |
Downloads
| MSDS | |
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| Info Sheet |
References
Fetoni AR, Bielefeld EC, Paludetti G, et al. A putative role of p53 pathway against impulse noise induced damage as demonstrated by protection with pifithrin-alpha and a Src inhibitor. Neurosci Res. 2014 Apr-May;81-82:30-7. PMID: 24472721.
Bielefeld EC, Hangauer D, Henderson D. Protection from impulse noise-induced hearing loss with novel Src-protein tyrosine kinase inhibitors. Neurosci Res. 2011 Dec;71(4):348-54. PMID: 21840347.
Harris KC, Hu B, Hangauer D, et al. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res. 2005 Oct;208(1-2):14-25. PMID: 15950415.