• Skip to primary navigation
  • Skip to main content
  • Skip to footer

LKT Labs

Biochemicals for Life Science Research

  • Products
    • New Products
    • Cancer Biology
    • Cardiovascular
    • Endocrine Signaling and Immunology
    • Metabolic and GI Pathology
    • Microbiology
    • Natural Products
    • Neuroscience
    • Peptides
    • Pharmaceutical Impurities and Derivatives
    • Stem Cell Modulators
  • Services
    • Custom Synthesis
    • Natural Product Isolation
    • Analytical Services
  • Int’l Distributors
  • Support
    • About LKT Labs
    • General Inquiry
    • Bulk Quote Request
    • Document Request
    • Technical Support
    • Catalog Request
    • Product Flyers
  • Contact Us
  • Cart
  • Login / Register
IC261

IC261

Product ID I0801
Cas No. 186611-52-9
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $188.00 In stock
25 mg $638.60 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

IC261 is most commonly known as an inhibitor of casein kinase 1. It has been shown to reduce pancreatic tumor cell growth in vitro and in vivo. In addition, it also inhibits sodium channels in human TsA cells. Furthermore, IC261 has also been found to inhibit microtubule polymerization. In inflammatory pain model mice, IC261 decreased the frequency and amplitude of spontaneous excitatory postsynaptic currents.

Product Info

Cas No.

186611-52-9

Purity

≥98%

Formula

C18H17NO4

Formula Wt.

311.12

Chemical Name

(3E)-3-(2,4,6-Trimethoxybenzylidene)-1,3-dihydro-2H-indol-2-one

IUPAC Name

(3E)-3-[(2,4,6-trimethoxyphenyl)methylidene]-1H-indol-2-one

Synonym

SU5607

Solubility

Soluble in DMSO (10 mg/ml). Insoluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

I0801 MSDS PDF

Info Sheet

I0801 Info Sheet PDF

References

Fohr KJ, Knippschild U, Herkommer A, et al. State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261. Invest New Drugs. 2017 Feb 6. Epub ahead of print. PMID: 28164251.

Stoter M, Kruger M, Banting G, et al. Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage. PLoS One. 2014 Jun 17;9(6):e100090. PMID: 24937750.

Kurihara T, Sakurai E, Toyomoto M, et al. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Mol Pain. 2014 Mar 10;10:17. PMID: 24612480.

Cheong JK, Nguyen TH, Wang H, et al. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ε and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene. 2011 Jun 2;30(22):2558-2569. PMID: 21256417.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
  • Total quantity of unit size desired (e.g. '10' in the case of 10 x 500 mg). If only one unit is desired, you may leave this blank.
  • This field is for validation purposes and should be left unchanged.

Related Products

  • E5568

    Enramycin A

    Polypeptide; peptidoglycan inhibitor.

    ≥95%
  • O938565

    6-Oxodocetaxel

    Docetaxel impurity

    ≥98%
  • C0021

    Cafestol Acetate

    Diterpene found in brewed, unfiltered coffee; F...

    ≥98%
  • A4803

    Amantadine Sulfate

    Viral M2 proton channel blocker, MAO-A, NET, NM...

    ≥98%
  • L1982

    Leupeptin Hemisulfate

    Protease inhibitor.

    ≥95%
  • B8144

    Bulleyaconitine A

    Found in Aconitum bulleyanum; voltage-gated Na+...

    ≥95%
  • B1855

    O6-Benzylguanine

    MGMT inhibitor.

    ≥98%
  • M7200

    MS436

    BRD4 inhibitor.

    ≥99%
  • L1782

    Levodopa

    Endogenous catecholamine precursor, also found ...

    ≥98%
  • A7034

    Aripiprazole

    D2 and 5-HT1A partial agonist, 5-HT2C/6/7 antag...

    ≥98%
  • F334451

    Filipin Complex

    A probe for cholesterol in biological membranes...

    ≥97%
  • M1977

    Metronidazole

    Nitroimidazole; DNA synthesis inhibitor.

    ≥98%
  • P465822

    Pluripotin

    Dual kinase and GTPase inhibitor.

    ≥98%
  • S8045

    S-Sulforaphane

    Synthetic antioxidant that induces phase II enz...

    ≥96%
  • F3207

    Fibronectin CS-1 Peptide

    Peptide; α4β1 integrin activator.

    ≥95%
  • C016481

    Camalexin

    Phytoalexin

    ≥98%
  • T982698

    L-Tyrosine disodium salt

    Amino acid precursor of dopamine.

    ≥98%
  • P2304

    Phalloidin

    Phallotoxin found in Amanita phalloides; microt...

    ≥90%
  • I7870

    Itraconazole

    Triazole; 14-α demethylase inhibitor, Smo modu...

    ≥98%
  • A6823

    Argatroban

    Thrombin inhibitor.

    ≥98%

Footer

  • Contact Us
  • About Us
  • Site Map
  • Terms and Conditions
LKT Laboratories, Inc.
545 Phalen Blvd.
St. Paul MN, 55130

Ph: (888)-558-5227
Fax: (888)-558-7329

©2025 LKT Laboratories, All Rights Reserved - Products for research use only