LKT Labs

Biochemicals for Life Science Research

Theaflavin-3-gallate

Theaflavin-3-gallate

Product ID T286165
Cas No. 30462-34-1
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $157.50 In stock
5 mg $630.00 In stock
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Description

Theaflavin-3-gallate is a polyphenolic compound found in black tea. The theaflavins are formed during the enzymatic oxidation of catechins, which happens during processing of the fresh tea leaves. Theaflavin-3-gallate has been shown to have inhibitory effects on ovarian cancer cells OVCAR-3 and A2780/CP70 by inducing apoptosis and impairing tumor angiogenesis. In addition, theaflavin-3-gallate was found to give stronger reactive oxygen species scavenging activity than theaflavin by a chemiluminescence assay. Exposure of CAL27 and HSC-2 carcinoma cells to theaflavin-3-gallate demostrated cytotoxic and antiproliferative properties of the compound.

Product Info

Cas No.

30462-34-1
Purity

≥95%
Formula

C36H28O16
Formula Wt.

716.60
IUPAC Name

(2R,3R)-5,7-Dihydroxy-2-{3,4,5-trihydroxy-6-oxo-1-[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-6H-benzo[7]annulen-8-yl}-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate

Shipping and Storage

Store Temp

4°C
Ship Temp

Ambient

Downloads

MSDS

T286165 MSDS PDF
Info Sheet

T286165 Info Sheet PDF

References

Gao Y, Rankin GO, Tu Y, et al. Inhibitory effects of the four main theaflavin derivatives found in black tea on ovarian cancer cells. Anticancer Res. 2016 Feb;36(2):643-651. PMID: 26851019.

Wu YY, Li W, Xu Y, et al. Evaluation of the antioxidant effects of four main theaflavin derivatives through chemiluminescence adn DNA damage analyses. J Zhejiang Univ Sci B. 2011 Sep;12(9):744-751. PMID: 21887850.

Babich H, Gottesman RT, Liebling EJ, et al. Theaflavin-3-gallate and theaflavin-3’-gallate, polyphenols in black tea with prooxidant properties. Basic Clin Pharmacol Toxicol. 2008 Jul;103(1):66-74. PMID: 18346048.

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