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α-Tocotrienol

Product ID T5608
Cas No. 58864-81-6
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $64.90 In stock
5 mg $181.50 In stock
10 mg $324.10 In stock
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  • Description
  • Product Info
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

Tocotrienols contain an arene ring, a chromanol ring, and an isoprenoid tail; all tocotrienol compounds contain a methyl group on C8 of the arene ring.
α-Tocotrienol contains two additional methyl groups arranged around the arene ring, positioned para and ortho to C8. Tocotrienols are members of the vitamin E family, typically found in vegetable oils, nuts, and grains. All tocotrienols exhibit strong antioxidative, anti-angiogenic, anticancer, and anti-hyperlipidemic qualities, although α-Tocotrienol displays the strongest antioxidative capacity. Tocopherols, common substituents of over-the-counter vitamin E supplements, interfere with tocotrienol activity and show weaker antioxidative effects. Tocotrienols exhibit significant radical recycling abilities in cellular models of lipid peroxidation and oxidative damage and suppress HMG-CoA reductase activity. In vitro, these compounds induce apoptosis through inhibition of Id1, EGFR, and NF-κB; they also inhibit vessel formation and proliferation in aortic endothelial cells.

Product Info

Cas No.

58864-81-6

Purity

≥98%

Formula

C29H44O2

Formula Wt.

424.66

IUPAC Name

(2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7, 11-trienyl]-3,4-dihydrochromen-6-ol

Synonym

alpha-tocotrienol

Solubility

Soluble in ethanol, hexanes, DMSO, DMF

Appearance

yellow liquid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T5608 MSDS PDF

Info Sheet

T5608 Info Sheet PDF

References

Yap WN, Chang PN, Han HY, et al. Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. Br J Cancer. 2008 Dec 2;99(11):1832-41. PMID: 19002171.

Sen CK, Khanna S, Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci. 2006 Mar 27;78(18):2088-98. PMID: 16458936.

Inokuchi H, Hirokane H, Tsuzuki T, et al. Anti-angiogenic activity of tocotrienol. Biosci Biotechnol Biochem. 2003 Jul;67(7):1623-7. PMID: 12913317.

Parker RA, Pearce BC, Clark RW, et al. Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1993 May 25;268(15):11230-8. PMID: 8388388.

Serbinova E, Kagan V, Han D, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med. 1991;10(5):263-75. PMID: 1649783.

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