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α-Melanocyte Stimulating Hormone

α-Melanocyte Stimulating Hormone

Product ID M7528
Cas No. 581-05-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $220.50 In stock
2.5 mg $315.00 In stock
5 mg $525.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

α Melanocyte-stimulating hormone (α-MSH) is an endogenous POMC-derived peptide in the pituitary involved in energy homeostasis and melanin production that activates melanocortin receptors. α-MSH exhibits anti-inflammatory, neuroprotective, cognition enhancing, anxiolytic, and antioxidative activities. In vivo, α-MSH decreases the intensity of acetaminophen-induced liver lesions. In animal models of Alzheimer’s disease, α-MSH prevents loss of GABAergic neurons, decreases anxiety levels, and improves spatial memory. α-MSH also decrease apoptosis and oxidative stress in diabetic retinas by inhibiting upregulation of Foxo4 induced by glucose.

Product Info

Cas No.

581-05-5

Purity

≥98%

Formula

C77H109N21O19S

Formula Wt.

1664.9

Synonym

alpha-MSH, alpha-Melanotropin, α-MSH

Solubility

Soluble in water (1 mg/mL).

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

M7528 MSDS PDF

Info Sheet

M7528 Info Sheet PDF

References

Ma K, McLaurin J. α-Melanocyte Stimulating Hormone Prevents GABAergic Neuronal Loss and Improves Cognitive Function in Alzheimer's Disease. J Neurosci. 2014 May 14;34(20):6736-45. PMID: 24828629.

Zhang L, Dong L, Liu X, et al. α-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes. PLoS One. 2014 Apr 2;9(4):e93433. PMID: 24695675.

Blagaić V, Houra K, Turcić P, et al. The influence of alpha-, beta-, and gamma-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Molecules. 2010 Mar 3;15(3):1232-41. PMID: 20335976.

Custom Order

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