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β-Endorphin, rat

β-Endorphin, rat

Product ID E5218
Cas No. 77367-63-6
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $283.50 Please Inquire
2 mg $525.00 Please Inquire
5 mg $1,029.00 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

β-Endorphin is an endogenous opioid peptide that acts as an agonist at μ-opioid receptors (μORs) and exhibits immunomodulatory, neuromodulatory, antidepressant, and antinociceptive/analgesic activities. In vivo, β-endorphin increases levels of B-cells and production of antibodies as well as secretion of IL-4 and proliferation of spleenocytes, shifting the immune response toward Th2-specific mediators. This peptide, like other endogenous opioids, plays a significant role in reward and reinforcement signaling, especially in brain regions such as the ventral tegmental area (VTA) and nucleus accumbens (NAcc). β-Endorphin release is induced during exercise and shows antidepressant activity in clinical studies.

Product Info

Cas No.

77367-63-6

Purity

≥95%

Formula

C157H254N42O44S

Formula Wt.

3466.09

Synonym

β-Lipotropin (61-91), rat; Proopiomelanocortin; POMC.

Solubility

Soluble in water.

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

E5218 MSDS PDF

Info Sheet

E5218 Info Sheet PDF

References

Charbogne P, Kieffer BL, Befort K. 15 years of genetic approaches in vivo for addiction research: Opioid receptor and peptide gene knockout in mouse models of drug abuse. Neuropharmacology. 2014 Jan;76 Pt B:204-17. PMID: 24035914.

Gein SV, Baeva TA, Nebogatikov VO, et al. β-Endorphin effects on antibody production, proliferation, and secretion of Th1/Th2 cytokines in vivo. Bull Exp Biol Med. 2012 Mar;152(5):595-9. PMID: 22803142.

Dinas PC, Koutedakis Y, Flouris AD. Effects of exercise and physical activity on depression. Ir J Med Sci. 2011 Jun;180(2):319-25. PMID: 21076975.

Horváth G, Mécs L. Antinociception by endogenous ligands at peripheral level. Ideggyogy Sz. 2011 Mar 30;64(5-6):193-207. PMID: 21688721.

Custom Order

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