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β-Rubromycin

β-Rubromycin

Product ID R8207
Cas No. 27267-70-5
Purity ≥98%
Product Unit SizeCostQuantityStock
1 mg $175.10 Please Inquire
5 mg $616.60 Please Inquire
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

β-Rubromycin is a quinolone antibiotic that directly inhibits telomerase; it exhibits some antibacterial and antiviral activities. β-Rubromycin inhibits HIV-1 reverse transcriptase and also displays anticancer potential, decreasing the proliferation of cancer cells in vitro.

Product Info

Cas No.

27267-70-5

Purity

≥98%

Formula

C27H20O12

Formula Wt.

536.44

Chemical Name

Spiro(benzo(1,2-b:5,4-c')dipyran-2(3H),2'(3'H)-naphtho(1,2-b)furan)-7-carboxylic acid,4,4',5',9-tetrahydro -6',10-dihydroxy-7',9'-dimethoxy-4',5',9-trioxo-, methyl ester

IUPAC Name

methyl (2S)-8',10-dihydroxy-5',7'-dimethoxy-4',9,9'-trioxospiro[3, 4-dihydropyrano[4,3-g]chromene-2, 2'-3H-benzo[f][1]benzofuran]-7-carboxylate

Appearance

Dark Purple Solid

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

R8207 MSDS PDF

Info Sheet

R8207 Info Sheet PDF

Brochures

Antivirals Booklet

References

Mizushina Y, Takeuchi T, Sugawara F, et al. Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid. Mini Rev Med Chem. 2012 Oct;12(11):1135-43. PMID: 22876944.

Ueno T, Takahashi H, Oda M, et al. Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry. 2000 May 23;39(20):5995-6002. PMID: 10821671.

Goldman ME, Salituro GS, Bowen JA, et al. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: competitive interaction at the template.primer site. Mol Pharmacol. 1990 Jul;38(1):20-5. PMID: 1695317.

Custom Order

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