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15-acetoxyscirpenol is a trichothecene mycotoxin initially produced by Fusarium that displays cytotoxicity in Jurkat T cells. This compound increases cleavage of poly(ADP)-ribose polymerase (PARP), activation of caspase 3, and DNA fragmentation, leading to apoptosis in vitro.
| Cas No. | 2623-22-5 |
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| Purity | ≥97% |
| Formula | C17H24O6 |
| Formula Wt. | 324.37 |
| Chemical Name | Trichothec-9-ene-3-alpha,4-beta,15-triol, 12,13-epoxy-, 15- acetate |
| IUPAC Name | [(1S,2R,7R,9R,10R,11S,12S)-10,11-dihydroxy-1,5-dimethylspiro[8-oxatricyclo[7.2.1.02,7]dodec-5-ene-12,2'-oxirane]-2-yl]methyl acetate |
| Synonym | 15-Acetoxyscirpen-3,4-diol, (3-alpha)-12,13-Epoxytrichothec-9-ene-3,4,15-triol 15- acetate |
| Solubility | Chloroform, ethyl acetate, acetone, DMSO |
| Appearance | White to off white powder |
| Store Temp | 4°C |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Lee DH, Park T, Kim HW. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull. 2006 Apr;29(4):648-54. PMID: 16595895.