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15,16-Dehydrocafestol

15,16-Dehydrocafestol

Product ID D1731
Cas No.
Purity ≥98%
Product Unit SizeCostQuantityStock
5 mg $337.10 In stock
10 mg $510.50 In stock
25 mg $1,021.00 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
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  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

15,16-Dehydrocafestol is a diterpene found in roasted coffee. This compound is a dehydration product of cafestol, which inhibits increases in pro-fibrotic cytokine TGF-β in models of liver damage and induces apoptosis through regulation of Sp1 signaling. 15,16-Dehydrocafestol exhibits anti-fibrotic, hepatoprotective, and anticancer activities. It may also induce apoptosis in malignant pleural mesothelioma cells.

Product Info

Purity

≥98%

Formula

C20H26O2

Formula Wt.

298.42

Synonym

Dehydrocafestol

Melting Point

110-112°C

Appearance

White Crystal Powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

D1731 MSDS PDF

Info Sheet

D1731 Info Sheet PDF

References

Arauz J, Moreno MG, Cortés-Reynosa P, et al. Coffee attenuates fibrosis by decreasing the expression of TGF-β and CTGF in a murine model of liver damage. J Appl Toxicol. 2013 Sep;33(9):970-9. PMID: 22899499.

Lee KA, Chae JI, Shim JH. Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma. J Biomed Sci. 2012 Jun 26;19:60. PMID: 22734486.

Custom Order

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