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2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

Product ID T1002
Cas No. 173101-54-7
Purity ≥95%
Product Unit SizeCostQuantityStock
1 mg $608.20 In stock
5 mg $2,232.20 In stock
10 mg $3,577.20 In stock
25 mg $7,011.50 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate) is an impurity of the chemotherapy drug paclitaxel. Is also known as paclitaxel impurity A or iso-cephalomannine.

Product Info

Cas No.

173101-54-7

Purity

≥95%

Formula

C45H53NO14

Formula Wt.

831.9

Chemical Name

2-Debenzoyl Paclitaxel-2-(2-Methyl-2-Butenoate)

IUPAC Name

[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] (E)-2-methylbut-2-enoate

Synonym

Paclitaxel 2-debenzoyl-2-(2-methyl-2-butenoate); Paclitaxel 2-debenzoyl pentenoate; iso-cephalomannine; paclitaxel impurity A

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

T1002 MSDS PDF

Info Sheet

T1002 Info Sheet PDF

References

Nicolaou K, Yang Z, Liu J, et al. Total synthesis of taxol. Nature. 1994 Feb 17;367(6464):630-634. PMID: 7906395.

Nicolaou K, Valiulin R. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Org Biomol Chem. 2013 Jul 7;11(25):4154-4163. PMID: 23685867.

Sanchez-Munoz R, Perez-Mata E, Almagro L, et al. A novel hydroxylation step in the taxane biosynthetic pathway: a new approach to paclitaxel production by synthetic biology. Front Bioeng Biotechnol. 2020 May 13;8::410. PMID: 32528936.

Guo B, Kai G, Jin H, et al. Taxol synthesis. African J Biotechnol. 2006 Jan 2;5(1):15-20.

Wang T, Chen Y, Zhuang W, et al. Transcriptome sequencing reveals regulatory mechanisms of taxol synthesis in Taxus wallichiana var. Mairei. Int J Genomics. 2019 May 2;2019:1596895. PMID: 31192250.

Custom Order

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