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4-Aminosalicylic acid exhibits anti-inflammatory, antioxidative, and antibacterial activities; it is clinically used to treat inflammatory bowel disease (IBD), Crohn’s disease, and colitis, as it acts primarily in the colon. 4-Aminosalicylic acid is used against Mycobacterium as a treatment for tuberculosis; it inhibits dihydrofolate reductase (DHFR) activity as an antimetabolite.
| Cas No. | 6018-19-5 |
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| Purity | ≥98% |
| Formula | C7H6NNaO3 • 2H2O |
| Formula Wt. | 211.15 |
| Chemical Name | 4-Amino-2-hydroxybenzoic acid sodium salt dihydrate |
| IUPAC Name | sodium;4-amino-2-hydroxybenzoate;dihydrate |
| Synonym | Aminacyl, Nemasol Sodium, Pamisyl Sodium, Pasalon |
| Melting Point | 250-254°C |
| Solubility | Soluble in water (500 mg/mL). Sparingly soluble in acetone. Practically insoluble in ether, chloroform and benzene. |
| Appearance | A white or almost white crystalline powder |
| Store Temp | Ambient |
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| Ship Temp | Ambient |
| MSDS | |
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| Info Sheet |
Dhaneshwar SS. Colon-specific prodrugs of 4-aminosalicylic acid for inflammatory bowel disease. World J Gastroenterol. 2014 Apr 7;20(13):3564-71. PMID: 24707139.
Jensen KA, Rosdahl KG, Ingvorsen H. Tuberculostatic derivatives of rho-aminobenzoic acid; esters and amides of 4-aminosalicylic acid. Acta Chem Scand. 1948;2(3):220-4. PMID: 18098531.