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5-Bromo-2′-Deoxyuridine

5-Bromo-2′-Deoxyuridine

Product ID B6856
Cas No. 59-14-3
Purity ≥98%
Product Unit SizeCostQuantityStock
250 mg $45.30 In stock
500 mg $75.10 In stock
1 g $112.60 In stock
5 g $443.30 In stock
Bulk Quote

Quicklinks

  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Description
  • Product Info
  • Shipping and Storage
  • Downloads
  • References
  • Custom Order

Description

5-Bromo-2’-deoxyuridine is a synthetic nucleoside analog of thymidine that is used in research models to label actively proliferating cells. This compound is incorporated into DNA but at low levels does not alter DNA replication. At high levels, this compound displays immunosuppressive activity and has shown some anticancer benefit when used as a chemotherapy radiosensitizer.

Product Info

Cas No.

59-14-3

Purity

≥98%

Formula

C9H11BrN2O5

Formula Wt.

307.11

Chemical Name

5-Bromo-2'-deoxyuridine

IUPAC Name

5-bromo-1-[(2R,4S, 5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Synonym

Broxuridine, 5-bromouracil deoxyriboside, BUdR, Broxine, Neomark, Radibud

Melting Point

187-189°C

Solubility

Soluble in dimethyl- acetamide, 1N NaOH, or DMSO. Slightly soluble in water.

Appearance

White crystalline powder

Shipping and Storage

Store Temp

-20°C

Ship Temp

Ambient

Downloads

MSDS

B6856 MSDS PDF

Info Sheet

B6856 Info Sheet PDF

References

Zhang R, Zhang J, Fang L, et al. Neuroprotective effects of sulforaphane on cholinergic neurons in mice with Alzheimer's disease-like lesions. Int J Mol Sci. 2014 Aug 18;15(8):14396-410. PMID: 25196440.

Jeong CH, Kim SM, Lim JY, et al. Mesenchymal stem cells expressing brain-derived neurotrophic factor enhance endogenous neurogenesis in an ischemic stroke model. Biomed Res Int. 2014;2014:129145. PMID: 24672780.

Russo A, Gianni L, Kinsella TJ, et al. Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors. Cancer Res. 1984 Apr;44(4):1702-5. PMID: 6704976.

Custom Order

  • Size of single unit expressed as number (e.g. '500' in the case of 500 mg)
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